Glucagon receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The glucagon family of receptors (nomenclature as agreed by NC-IUPHAR Subcommittee on the Glucagon receptor family, [14]) are activated by the endogenous peptide (27–44 aa) hormones glucagon (GCG, P01275), glucagon-like peptide 1 (GLP-1 (GCG, P01275)), glucagon-like peptide 2 (GLP-2 (GCG, P01275)), glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide or GIP (GIP, P09681), GHRH (GHRH, P01286) and secretin (SCT, P09683). One common precursor (GCG) generates glucagon (GCG, P01275), GLP-1 (GCG, P01275) and GLP-2 (GCG, P01275) peptides [9].

Receptors

GHRH receptor Show summary » More detailed page

GIP receptor Show summary » More detailed page

GLP-1 receptor Show summary » More detailed page

GLP-2 receptor Show summary » More detailed page

glucagon receptor Show summary » More detailed page

secretin receptor Show summary » More detailed page

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Glucagon receptor family. Accessed on 25/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=29.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.