Adenosine receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [19]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound and agonist-bound A2A adenosine receptors have been described [26,66].


A1 receptor Show summary » More detailed page

A2A receptor Show summary » More detailed page

A2B receptor Show summary » More detailed page

A3 receptor Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adriaan P. IJzerman, Bertil B. Fredholm, Kenneth A. Jacobson, Joel Linden, Christa E. Müeller, Bruno G. Frenguelli, Ulrich Schwabe, Gary L. Stiles, Rebecca Hills, Karl-Norbert Klotz. Adenosine receptors. Accessed on 27/11/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.