Type XIII RTKs: Ephrin receptor family C

Formerly known as: Ephrin receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Ephrin receptors are a family of 15 RTKs (the largest family of RTKs) with two identified subfamilies (EphA and EphB), which have a role in the regulation of neuronal development, cell migration, patterning and angiogenesis. Their ligands are membrane-associated proteins, thought to be glycosylphosphatidylinositol-linked for EphA (ephrin-A1 (EFNA1, P20827) , ephrin-A2 (EFNA2, O43921), ephrin-A3 (EFNA3, P52797), ephrin-A4 (EFNA4, P52798) and ephrin-A5 (EFNA5, P52803)) and 1TM proteins for Ephrin B (ENSFM00250000002014: ephrin-B1 (EFNB1, P98172), ephrin-B2 (EFNB2, P52799) and ephrin-B3 (EFNB3, Q15768)), although the relationship between ligands and receptors has been incompletely defined.

Receptors

EphA1 (EPH receptor A1) C Show summary » More detailed page

EphA2 (EPH receptor A2) C Show summary » More detailed page

EphA3 (EPH receptor A3) C Show summary » More detailed page

EphA4 (EPH receptor A4) C Show summary » More detailed page

EphA5 (EPH receptor A5) C Show summary » More detailed page

EphA6 (EPH receptor A6) C Show summary » More detailed page

EphA7 (EPH receptor A7) C Show summary » More detailed page

EphA8 (EPH receptor A8) C Show summary » More detailed page

EphA10 (EPH receptor A10) C Show summary » More detailed page

EphB1 (EPH receptor B1) C Show summary » More detailed page

EphB2 (EPH receptor B2) C Show summary » More detailed page

EphB3 (EPH receptor B3) C Show summary » More detailed page

EphB4 (EPH receptor B4) C Show summary » More detailed page

EphB6 (EPH receptor B6) C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Type XIII RTKs: Ephrin receptor family. Accessed on 20/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=327.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.