Orexin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [5]) are activated by the endogenous polypeptides orexin-A (HCRT, O43612) and orexin-B (HCRT, O43612) (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage [26].

Receptors

OX1 receptor C Show summary » More detailed page

OX2 receptor C Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Christopher J. Winrow, Paul Coleman, Luis de Lecea, Thomas Kilduff, Jyrki P. Kukkonen, Rod Porter, John Renger, Jerome M Siegel, Gregor Sutcliffe, Jim Hagan, Anthony Gotter, Neil Upton, Rebecca Hills. Orexin receptors. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=51.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.