P2Y receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [1-2]) are activated by the endogenous ligands ATP, adenosine diphosphate, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as ‘uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor’ or ‘P2Y1-like’, etc., until further, as yet undefined, corroborative criteria can be applied [13,24,36,65,69].

Receptors

P2Y1 receptor Show summary » More detailed page

P2Y2 receptor Show summary » More detailed page

P2Y4 receptor Show summary » More detailed page

P2Y6 receptor Show summary » More detailed page

P2Y11 receptor Show summary » More detailed page

P2Y12 receptor Show summary » More detailed page

P2Y13 receptor Show summary » More detailed page

P2Y14 receptor Show summary » More detailed page

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Geoffrey Burnstock, Maria-Pia Abbracchio, Jean-Marie Boeynaems, José L. Boyer, Stefania Ceruti, Marta Fumagalli, Christian Gachet, Robert G. Humphries, Kenneth A. Jacobson, Charles Kennedy, Brian F. King, Davide Lecca, Maria Teresa Miras-Portugal, Gary A. Weisman, Rebecca Hills. P2Y receptors. Accessed on 01/09/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=52.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.