Platelet-activating factor receptor

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles. The PAF receptor (provisional nomenclature recommended by NC-IUPHAR [2]) is activated by PAF and other suggested endogenous ligands are oxidized phosphatidylcholine [7] and lysophosphatidylcholine [10]. It may also be activated by bacterial lipopolysaccharide [9].

Receptors

PAF receptor Show summary » More detailed page

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Ewa Ninio, Satoshi Ishii, Sonia Jancar, Francisco Jose Oliveira Rios, Thomas McIntyre, Chris O'Neill, Jeffery B. Travers, Mark Whittaker, Rebecca Hills. Platelet-activating factor receptor. Accessed on 31/08/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=55.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.