Trace amine receptor

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Trace amine-associated receptors (nomenclature as agreed by NC-IUPHAR for trace amine receptors, [3]) were initially discovered as a result of a search for novel 5-HT receptors [1], where 15 mammalian orthologues were identified and divided into two families. The TA1 receptor has been shown to have affinity for the endogenous trace amines tyramine, PEA and octopamine in addition to the classical amine dopamine [1]. Emerging evidence suggests that TA1 is a modulator of monoaminergic activity in the brain [6] with TA1 and dopamine D2 receptors shown to form constitutive heterodimers when co-expressed [2].

Receptors

TA1 receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Trace amine receptor. Accessed on 20/12/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=64.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.