Trace amine receptor

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Trace amine-associated receptors (nomenclature as agreed by NC-IUPHAR for trace amine receptors, [3]) were initially discovered as a result of a search for novel 5-HT receptors [1], where 15 mammalian orthologues were identified and divided into two families. The TA1 receptor has been shown to have affinity for the endogenous trace amines tyramine, β-phenylethylamine and octopamine in addition to the classical amine dopamine [1]. Emerging evidence suggests that TA1 is a modulator of monoaminergic activity in the brain [6] with TA1 and dopamine D2 receptors shown to form constitutive heterodimers when co-expressed [2].

Receptors

TA1 receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Trace amine receptor. Accessed on 19/09/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=64.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.