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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Trace amine-associated receptors (nomenclature as agreed by NC-IUPHAR for trace amine receptors, ) were initially discovered as a result of a search for novel 5-HT receptors , where 15 mammalian orthologues were identified and divided into two families. The TA1 receptor has been shown to have affinity for the endogenous trace amines tyramine, PEA and octopamine in addition to the classical amine dopamine . Emerging evidence suggests that TA1 is a modulator of monoaminergic activity in the brain  with TA1 and dopamine D2 receptors shown to form constitutive heterodimers when co-expressed .
* Key recommended reading is highlighted with an asterisk
* Burchett SA, Hicks TP. (2006) The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain. Prog. Neurobiol., 79 (5-6): 223-46. [PMID:16962229]
* Grandy DK. (2007) Trace amine-associated receptor 1-Family archetype or iconoclast?. Pharmacol Ther, 116: 355-390. [PMID:17888514]
* Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP. (2009) International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev., 61 (1): 1-8. [PMID:19325074]
* Miller GM. (2011) The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J. Neurochem., 116 (2): 164-76. [PMID:21073468]
* Sotnikova TD, Caron MG, Gainetdinov RR. (2009) Trace amine-associated receptors as emerging therapeutic targets. Mol. Pharmacol., 76 (2): 229-35. [PMID:19389919]
* Zucchi R, Chiellini G, Scanlan TS, Grandy DK. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149: 967-978. [PMID:17088868]
1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 98: 8966-8971. [PMID:11459929]
2. Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, Caron MG, Gainetdinov RR. (2011) Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol. Pharmacol., 80 (3): 416-25. [PMID:21670104]
3. Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP. (2009) International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev., 61 (1): 1-8. [PMID:19325074]
4. Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. (2004) 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med, 10: 638-642. [PMID:15146179]
5. Stalder H, Hoener MC, Norcross RD. (2011) Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773). Bioorg. Med. Chem. Lett., 21 (4): 1227-31. [PMID:21237643]
6. Xie Z, Miller GM. (2009) Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochem. Pharmacol., 78 (9): 1095-104. [PMID:19482011]
Database page citation:
Trace amine receptor. Accessed on 05/03/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=64.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.