Urotensin receptor

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The urotensin-II (U-II) receptor (UT, nomenclature as agreed by NC-IUPHAR, [8,11]) is activated by the endogenous dodecapeptide U-II (UTS2, O95399), originally isolated from the urophysis, the endocrine organ of the caudal neurosecretory system of teleost fish [2]. Several structural forms of U-II exist in fish and amphibians. The Goby orthologue was used to identify U-II as the cognate ligand for the predicted receptor encoded by the rat gene gpr14 [6,17,20-21]. Human U-II (UTS2, O95399), an 11-amino-acid peptide [6], retains the cyclohexapeptide sequence of goby U-II that is thought to be important in ligand binding [3,13]. This sequence is also conserved in the deduced amino-acid sequence of rat U-II (14 amino-acids) and mouse U-II (14 amino-acids), although the N-terminal is more divergent from the human sequence [5]. A second endogenous ligand for UT has been discovered in rat [25]. The urotensin II-related peptide (URP (UTS2B, Q765I0)), an octapeptide, is derived from a different gene, but shares the C-terminal sequence (CFWKYCV) common to U-II from other species. Identical sequences to rat URP (UTS2B, Q765I0) are predicted for the mature mouse and human peptides.


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Urotensin receptor. Accessed on 01/03/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=65.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.