Apelin receptor

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The apelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the apelin receptor [14]) responds to apelin, a 36 amino-acid peptide derived initially from bovine stomach. Apelin-36 (APLN, Q9ULZ1), apelin-13 (APLN, Q9ULZ1) and [Pyr1]apelin-13 (APLN, Q9ULZ1) are the predominant endogenous ligands which are cleaved from a 77 amino-acid precursor peptide (APLN, Q9ULZ1) by a so far unidentified enzymatic pathway [15]. A second family of peptides discovered independently and named Elabela [3] or Toddler, that has little sequence similarity to apelin, has been proposed as a second endogenous apelin receptor ligand [13].

Receptors

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Anthony P. Davenport, Matthias Kleinz, Janet J. Maguire, Peiran Yang. Apelin receptor. Accessed on 29/09/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=7.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.