2B. Retinoid X receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Retinoid X receptors (nomenclature as agreed by NC-IUPHAR Committee on Nuclear Receptors, [5]) are NR2B family members activated by alitretinoin and the RXR-selective agonists bexarotene and LG100268, sometimes referred to as rexinoids. UVI3003 [8] and HX531 [4] have been described as a pan-RXR antagonists. These receptors form RXR–RAR heterodimers and RXR–RXR homodimers [3,7].

Receptors

Retinoid X receptor-α / NR2B1 Show summary » More detailed page

Retinoid X receptor-β / NR2B2 Show summary » More detailed page

Retinoid X receptor-γ / NR2B3 Show summary » More detailed page

Further reading

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References

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How to cite this family page

Database page citation:

2B. Retinoid X receptors. Accessed on 31/07/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=92.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Nuclear Hormone Receptors. Br J Pharmacol. 170: 1652–1675.