1.1.1.42 Isocitrate dehydrogenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.

Enzymes

isocitrate dehydrogenase (NADP(+)) 1, cytosolic / IDH1 C Show summary »« Hide summary More detailed page

Target Id

2884

Nomenclature

isocitrate dehydrogenase (NADP(+)) 1, cytosolic

Systematic nomenclature

IDH1

Previous and unofficial names

isocitrate dehydrogenase 1 (NADP+), soluble | isocitrate dehydrogenase [NADP] cytoplasmic | isocitrate dehydrogenase 1 (NADP) | isocitrate dehydrogenase 1 (NADP+)

Genes

IDH1 (Hs), Idh1 (Mm), Idh1 (Rn)

Ensembl ID

ENSG00000138413 (Hs), ENSMUSG00000025950 (Mm), ENSRNOG00000015020 (Rn)

UniProtKB AC

O75874 (Hs), O88844 (Mm), P41562 (Rn)

EC number

1.1.1.42	Isocitrate + NADP(+) <=> 2-oxoglutarate + CO₂ + NADPH
Isocitrate + NADP+ <=> 2-oxoglutarate + CO₂ + NADPH

Inhibitors

AGI-5198 pK_i 4.9

Selective inhibitors

ivosidenib [1]

isocitrate dehydrogenase (NADP(+)) 2, mitochondrial / IDH2 C Show summary »« Hide summary More detailed page

Target Id	2885
Nomenclature	isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Systematic nomenclature	IDH2
Previous and unofficial names	IDH-2 \| IDPm \| isocitrate dehydrogenase 2 (NADP+), mitochondrial \| isocitrate dehydrogenase 2 (NADP), mitochondrial \| isocitrate dehydrogenase 2 (NADP+)
Genes	IDH2 (Hs), Idh2 (Mm), Idh2 (Rn)
Ensembl ID	ENSG00000182054 (Hs), ENSMUSG00000030541 (Mm), ENSRNOG00000013949 (Rn)
UniProtKB AC	P48735 (Hs), P54071 (Mm), P56574 (Rn)

References

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How to cite this family page

Database page citation:

1.1.1.42 Isocitrate dehydrogenases. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=922.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.