1.1.1.42 Isocitrate dehydrogenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.

Enzymes

isocitrate dehydrogenase (NADP(+)) 1, cytosolic / IDH1 C Show summary » More detailed page

isocitrate dehydrogenase (NADP(+)) 2, mitochondrial / IDH2 C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

1.1.1.42 Isocitrate dehydrogenases. Accessed on 20/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=922.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.