Sphingomyelin synthase: Introduction

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Genetic studies in mice have identified sphingomyelin synthase as a novel molecular target for pharmaceutical intervention in atherosclerosis [2,4,6], obesity and insulin resistance [5]. As a result of these findings, small molecule inhibitors of sphingomyelin synthase are being investigated for their potential to provide novel therapeutics for the treatment of treatment these metabolic diseases [1,3,7].


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1. Deng X, Lin F, Zhang Y, Li Y, Zhou L, Lou B, Li Y, Dong J, Ding T, Jiang X et al.. (2014) Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem, 73: 1-7. [PMID:24374347]

2. Jiang X-C, Yeang C, Li Z, Chakraborty M, Zhang H, Fan Y. (2009) Sphingomyelin biosynthesis: its impact on lipid metabolism and atherosclerosis. Clinical Lipidology, 4 (5): 595-609.

3. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg. Med. Chem., 23 (18): 6173-84. [PMID:26314925]

4. Li Z, Fan Y, Liu J, Li Y, Huan C, Bui HH, Kuo MS, Park TS, Cao G, Jiang XC. (2012) Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol., 32 (7): 1577-84. [PMID:22580896]

5. Li Z, Zhang H, Liu J, Liang CP, Li Y, Li Y, Teitelman G, Beyer T, Bui HH, Peake DA et al.. (2011) Reducing plasma membrane sphingomyelin increases insulin sensitivity. Mol. Cell. Biol., 31 (20): 4205-18. [PMID:21844222]

6. Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo MS, Cao G, Jiang XC. (2009) Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Circ. Res., 105 (3): 295-303. [PMID:19590047]

7. Young SA, Mina JG, Denny PW, Smith TK. (2012) Sphingolipid and ceramide homeostasis: potential therapeutic targets. Biochem Res Int, 2012: 248135. [PMID:22400113]

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To cite this family introduction, please use the following:

Sphingomyelin synthase, introduction. Last modified on 23/09/2015. Accessed on 21/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=774.