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ChEMBL ligand: CHEMBL350775 (Biricodar) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
ChEMBL | Binding affinity to FKBP12 by fluorescence polarization assay | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] | ||||||||
ChEMBL | Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay | B | 5.13 | pIC50 | 7370 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] | ||||||||
ChEMBL | Inhibition of multidrug resistance associated protein type 1 (MRP1) assayed by an accumulation assay in COR.L23/R cells | F | 5.29 | pIC50 | 5180 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-574 [PMID:11844674] |
GtoPdb | - | - | 5.29 | pIC50 | 5180 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-4 [PMID:11844674] |
FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] | ||||||||
ChEMBL | Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay | B | 5.07 | pIC50 | 8520 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795] | ||||||||
ChEMBL | Inhibitory activity against P-glycoprotein (Pgp) using accumulation assay for Pgp expressing EMT6/AR1.0 cells. | F | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-574 [PMID:11844674] |
ABCB1 in Human [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 571-4 [PMID:11844674] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]