ABCC1

Target id: 779

Nomenclature: ABCC1

Abbreviated Name: MRP1

Systematic Nomenclature: ABCC1

Family: ABCC subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 17 1531 16p13.1 ABCC1 ATP binding cassette subfamily C member 1
Mouse 17 1528 16 9.75 cM Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Rat 17 1532 10q11 Abcc1 ATP binding cassette subfamily C member 1
Previous and Unofficial Names
leukotriene C4 transporter
GS-X
MRP
multidrug resistance associated protein 1
Abcc1a
ATP-binding cassette sub-family C (CFTR/MRP) member 1 (multiple drug resistance-associated protein)
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1a
Avcc1a
LTC4 transporter
Multidrug resistance protein 1
Abcc1b
Mdrap
ATP-binding cassette sub-family C (CFTR/MRP) member 1a
MRP1
ATP-binding cassette, subfamily C (CFTR/MRP), member 1
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
KEGG Gene
OMIM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of the human multidrug resistance protein 1 nucleotide binding domain 1
PDB Id:  2CBZ
Resolution:  1.5Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
WP814 Hs Inhibition 7.2 pKi 1
pKi 7.2 (Ki 7x10-8 M) [1]

References

Show »

1. Priebe W, Krawczyk M, Kuo MT, Yamane Y, Savaraj N, Ishikawa T. (1998) Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem. Biophys. Res. Commun.247 (3): 859-63. [PMID:9647783]

2. Ramaen O, Leulliot N, Sizun C, Ulryck N, Pamlard O, Lallemand JY, Tilbeurgh Hv, Jacquet E. (2006) Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J. Mol. Biol.359 (4): 940-9. [PMID:16697012]

Contributors

Show »

How to cite this page

Mary Vore.
ABCC subfamily: ABCC1. Last modified on 11/09/2015. Accessed on 23/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=779.