ABCC1

Target id: 779

Nomenclature: ABCC1

Abbreviated Name: MRP1

Systematic Nomenclature: ABCC1

Family: ABCC subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ABCC1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 17 1531 16p13.1 ABCC1 ATP binding cassette subfamily C member 1
Mouse 17 1528 16 9.75 cM Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Rat 17 1532 10q11 Abcc1 ATP binding cassette subfamily C member 1
Previous and Unofficial Names
leukotriene C4 transporter | GS-X | MRP | multidrug resistance associated protein 1 | Abcc1a | ATP-binding cassette sub-family C (CFTR/MRP) member 1 (multiple drug resistance-associated protein) | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1a | Avcc1a | LTC4 transporter | Multidrug resistance protein 1 | Abcc1b | Mdrap | ATP-binding cassette sub-family C (CFTR/MRP) member 1a | MRP1 | ATP-binding cassette, subfamily C (CFTR/MRP), member 1
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of the human multidrug resistance protein 1 nucleotide binding domain 1
PDB Id:  2CBZ
Resolution:  1.5Å
Species:  Human
References:  2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
WP814 Hs Inhibition 7.2 pKi 1
pKi 7.2 (Ki 7x10-8 M) [1]

References

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1. Priebe W, Krawczyk M, Kuo MT, Yamane Y, Savaraj N, Ishikawa T. (1998) Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem. Biophys. Res. Commun.247 (3): 859-63. [PMID:9647783]

2. Ramaen O, Leulliot N, Sizun C, Ulryck N, Pamlard O, Lallemand JY, Tilbeurgh Hv, Jacquet E. (2006) Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J. Mol. Biol.359 (4): 940-9. [PMID:16697012]

Contributors

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How to cite this page

Mary Vore.
ABCC subfamily: ABCC1. Last modified on 11/09/2015. Accessed on 24/08/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=779.