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ChEMBL ligand: CHEMBL457748 (Mb-07811, Mb07811, MB07811, Vk-2809, VK2809) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] | ||||||||
ChEMBL | Binding affinity to TRalpha1 | B | 4.9 | pKi | 12500 | nM | Ki | J Med Chem (2012) 55: 5649-5675 [PMID:22512468] |
GtoPdb | Binding affinity for human THRα | - | 7.45 | pKi | 35.2 | nM | Ki | J Med Chem (2008) 51: 7075-93 [PMID:18975928] |
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] | ||||||||
ChEMBL | Binding affinity to TRbeta1 | B | 6.22 | pKi | 600 | nM | Ki | J Med Chem (2012) 55: 5649-5675 [PMID:22512468] |
GtoPdb | Binding affinity for human THRβ | - | 8.53 | pKi | 2.95 | nM | Ki | J Med Chem (2008) 51: 7075-93 [PMID:18975928] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]