Thyroid hormone receptor-α

Nomenclature: Thyroid hormone receptor-α

Systematic Nomenclature: NR1A1

Family: 1A. Thyroid Hormone Receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 410 17q21.1 THRA thyroid hormone receptor, alpha 18
Mouse 410 11 D-E; 11 57.0 cm Thra thyroid hormone receptor alpha 29
Rat 410 10q31 Thra thyroid hormone receptor alpha 20
Previous and Unofficial Names
EAR-7.1/EAR-7.2
THRA3
AR7
ERBA
TRα
THRA
erbAα
erbA1
EAR7
THRA1
THRA2
NR1A1
thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog)
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
C-erbA-alpha
Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1)
Thyroid hormone receptor, alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1, formerly ERBA1)
avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1
c-erb-A thyroid hormone receptor
c-erbA-1
c-erbA-alpha2
nuclear receptor subfamily 1 group A member 1
thyroid hormone receptor
thyroid hormone receptor alpha
T3R[a]
T3Ralpha
TR alpha 1
c-erbAalpha
TR alpha 2
Rvr
6430529J03Rik
AW259572
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Thyroid hormone receptor-α (Ligand Binding Domain) - cocrystallised with agonist
PDB Id:  3JZB
Ligand:  tiratricol
Resolution:  2.01Å
Species:  Human
References:  17
Natural/Endogenous Ligands
T3
T4
Comments: T3 is the more potent endogenous ligand
Rank order of potency (Human)
T3 > T4
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
T3 Hs Agonist 10.0 pKd 24
pKd 10.0 [24]
GC-1 Hs Agonist 9.36 pKd 25
pKd 9.36 [25]
KB-141 Hs Agonist 7.6 pIC50 30
pIC50 7.6 [30]
rT3 Hs Agonist - pIC50 25
pIC50 [25]
T4 Hs Agonist - pIC50 25
pIC50 [25]
tiratricol Hs Agonist - pIC50 25
pIC50 [25]
dextrothyroxine Hs Agonist - - 1
[1]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
NH-3 Hs Antagonist 7.62 pKd 24
pKd 7.62 [24]
Antagonist Comments
NH-3 prevents co-activator recruitment without recruiting co-repressor and is marginally selective for TRα1 (approximately 5 times more selective).
DNA Binding
Structure:  Monomer, Heterodimer, RXR partner
HRE core sequence:  AGGTCA
Response element:  DR4, Palindrome
Co-binding Partners
Name Interaction Effect Reference
RXR Physical, Functional DNA binding 5
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOR1 Co-repressor No No No 12
NCOA3 Co-activator No No No 3
NCOR2 Co-repressor No No No 4
NCOA2 Co-activator No Yes Yes 16
NCOA1 Co-activator No Yes Yes 23
MED1 Co-activator No No No 13
Main Target Genes
Name Species Effect Technique Comments References
Hcn2 Mouse Activated 10
Hairless Mouse Activated Regulated only in brain. Encodes a corepressor. 26
Gh Mouse None Footprint, transient transfection 14
Tissue Distribution
Ubiquitous
Species:  Mouse
Technique:  In situ hybridisation
References:  11
Functional Assays
Cardiac response
Species:  Mouse
Tissue:  Heart
Response measured:  heart rate
References:  28
Physiological Consequences of Altering Gene Expression
Pleiotropic (usually viable and fertile)
Species:  Mouse
Tissue: 
Technique:  Knockout
References:  6-9,15
Dwarfism, obesity
Species:  Mouse
Tissue: 
Technique:  Knock-in mutation alteration of the AF2 domain
References:  15,27
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0001777 abnormal body temperature regulation PMID: 12869545 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0001777 abnormal body temperature regulation PMID: 17622582 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0002896 abnormal bone mineralization PMID: 16051666 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003795 abnormal bone structure PMID: 17327419 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003795 abnormal bone structure PMID: 16051666 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0000130 abnormal cancellous bone morphology PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0000130 abnormal cancellous bone morphology PMID: 17327419 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0000130 abnormal cancellous bone morphology PMID: 11731613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0000130 abnormal cancellous bone morphology PMID: 16051666 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac
MGI:98742  MP:0004039 abnormal cardiac cell glucose uptake PMID: 15304375 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0000872 abnormal cerebellum external granule cell layer morphology PMID: 16131613 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0000872 abnormal cerebellum external granule cell layer morphology PMID: 17622582 
Tg(CAG-cre/Esr1*)5Amc|Thra+|Thratm1Ffla Tg(CAG-cre/Esr1*)5Amc/?,Thratm1Ffla/Thra+
involves: 129/Sv * C57BL/6 * CBA
MGI:2182765  MGI:98742  MP:0000849 abnormal cerebellum morphology PMID: 17622582 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0009780 abnormal chondrocyte physiology PMID: 17065405 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 11739587 
Thratm1Ven Thratm1Ven/Thratm1Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0004399 abnormal cochlear outer hair cell morphology PMID: 16803873 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004434 abnormal cochlear outer hair cell physiology PMID: 11739587 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003796 abnormal cortical bone morphology PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003796 abnormal cortical bone morphology PMID: 11731613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003796 abnormal cortical bone morphology PMID: 16051666 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0002835 abnormal cranial suture morphology PMID: 16051666 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0003866 abnormal defecation PMID: 12869545 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0000479 abnormal enterocyte morphology PMID: 11416151 
Thratm3Jas Thratm3Jas/Thratm3Jas
involves: 129/Sv
MGI:98742  MP:0008882 abnormal enterocyte physiology PMID: 11416151 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0008882 abnormal enterocyte physiology PMID: 11416151 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0008882 abnormal enterocyte physiology PMID: 11416151 
Thratm3Jas Thratm3Jas/Thratm3Jas
involves: 129/Sv
MGI:98742  MP:0008883 abnormal enterocyte proliferation PMID: 11416151 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0008883 abnormal enterocyte proliferation PMID: 11416151 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0008883 abnormal enterocyte proliferation PMID: 11416151 
Thratm3Jas Thratm3Jas/Thratm3Jas
involves: 129/Sv
MGI:98742  MP:0005584 abnormal enzyme/coenzyme activity PMID: 11416151 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0005584 abnormal enzyme/coenzyme activity PMID: 11416151 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005584 abnormal enzyme/coenzyme activity PMID: 12869545 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0005584 abnormal enzyme/coenzyme activity PMID: 11416151 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0000084 abnormal fontanelle morphology PMID: 16051666 
Tg(CAG-cre/Esr1*)5Amc|Thra+|Thratm1Ffla Tg(CAG-cre/Esr1*)5Amc/?,Thratm1Ffla/Thra+
involves: 129/Sv * C57BL/6 * CBA
MGI:2182765  MGI:98742  MP:0001629 abnormal heart rate PMID: 17622582 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0000807 abnormal hippocampus morphology PMID: 16131613 
Thratm3Jas Thratm3Jas/Thratm3Jas
involves: 129/Sv
MGI:98742  MP:0003449 abnormal intestinal goblet cells PMID: 11416151 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003449 abnormal intestinal goblet cells PMID: 11416151 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0003449 abnormal intestinal goblet cells PMID: 11416151 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0000511 abnormal intestinal mucosa morphology PMID: 11416151 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0000511 abnormal intestinal mucosa morphology PMID: 11416151 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0003312 abnormal locomotor coordination PMID: 16131613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0006399 abnormal long bone epiphyseal ossification zone morphology PMID: 16051666 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003055 abnormal long bone epiphyseal plate morphology PMID: 17327419 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003055 abnormal long bone epiphyseal plate morphology PMID: 16051666 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0003055 abnormal long bone epiphyseal plate morphology PMID: 9927422 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0003055 abnormal long bone epiphyseal plate morphology PMID: 9927422 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003662 abnormal long bone epiphyseal plate proliferative zone PMID: 16051666 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001458 abnormal object recognition memory PMID: 16131613 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0000042 abnormal organ of Corti PMID: 11739587 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001541 abnormal osteoclast physiology PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0001541 abnormal osteoclast physiology PMID: 17327419 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0003825 abnormal pillar cell morphology PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0003965 abnormal pituitary hormone level PMID: 17210747 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001731 abnormal postnatal growth PMID: 12356724 
Thratm1Ven|Thratm3Ven Thratm1Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001731 abnormal postnatal growth PMID: 12356724 
Thra+|Thratm3Ven|Thrb+|Thrbtm1Df Thratm3Ven/Thra+,Thrbtm1Df/Thrb+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0001731 abnormal postnatal growth PMID: 12356724 
Tg(CAG-cre/Esr1*)5Amc|Thra+|Thratm1Ffla Tg(CAG-cre/Esr1*)5Amc/?,Thratm1Ffla/Thra+
involves: 129/Sv * C57BL/6 * CBA
MGI:2182765  MGI:98742  MP:0001731 abnormal postnatal growth PMID: 17622582 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001384 abnormal pup retrieval PMID: 11731613 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0008572 abnormal Purkinje cell dendrite morphology PMID: 17622582 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 17327419 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0002113 abnormal skeleton development PMID: 9927422 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0008108 abnormal small intestinal villus morphology PMID: 11416151 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0008108 abnormal small intestinal villus morphology PMID: 11416151 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0000496 abnormal small intestine morphology PMID: 9927422 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0000496 abnormal small intestine morphology PMID: 9927422 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0002674 abnormal sperm motility PMID: 17210747 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0003149 abnormal tectorial membrane morphology PMID: 11739587 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0004696 abnormal thyroid follicle morphology PMID: 11731613 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 11726557 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 9927422 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0004696 abnormal thyroid follicle morphology PMID: 9927422 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0005468 abnormal thyroid hormone level PMID: 11726557 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0002876 abnormal thyroid physiology PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0002876 abnormal thyroid physiology PMID: 11731613 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003971 abnormal thyroid-stimulating hormone level PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003971 abnormal thyroid-stimulating hormone level PMID: 11731613 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0001393 ataxia PMID: 17622582 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003503 decreased activity of thyroid PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003503 decreased activity of thyroid PMID: 17327419 
Thratm1Ven Thratm1Ven/Thratm1Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003503 decreased activity of thyroid PMID: 9430637 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003503 decreased activity of thyroid PMID: 11731613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0003503 decreased activity of thyroid PMID: 11734632 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0001258 decreased body length PMID: 11734632 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001265 decreased body size PMID: 11739587 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005534 decreased body temperature PMID: 12869545 
Thratm1Ven Thratm1Ven/Thratm1Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005534 decreased body temperature PMID: 9430637 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001262 decreased body weight PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0001262 decreased body weight PMID: 17327419 
Thratm3Ven Thratm3Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001262 decreased body weight PMID: 12356724 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001262 decreased body weight PMID: 12356724 
Thratm1Ven|Thratm3Ven Thratm1Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001262 decreased body weight PMID: 12356724 
Thratm2Ven|Thratm3Ven Thratm2Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001262 decreased body weight PMID: 12356724 
Thra+|Thratm3Ven|Thrb+|Thrbtm1Df Thratm3Ven/Thra+,Thrbtm1Df/Thrb+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 12356724 
Thra+|Thratm3Ven|Thrbtm1Df Thratm3Ven/Thra+,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 12356724 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 17210747 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001262 decreased body weight PMID: 11731613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0001262 decreased body weight PMID: 11734632 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac
MGI:98742  MP:0001262 decreased body weight PMID: 15304375 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 9927422 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0010124 decreased bone mineral content PMID: 11731613 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0010121 decreased bone mineral density PMID: 11731613 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 11739587 
Thra+|Thratm1Ven|Thrbtm1Df Thratm1Ven/Thra+,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 11739587 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0004701 decreased circulating insulin-like growth factor I level PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0004701 decreased circulating insulin-like growth factor I level PMID: 17327419 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0004701 decreased circulating insulin-like growth factor I level PMID: 11731613 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005119 decreased circulating thyroid-stimulating hormone level PMID: 12576486 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005478 decreased circulating thyroxine level PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0005478 decreased circulating thyroxine level PMID: 11159823  17327419 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0005478 decreased circulating thyroxine level PMID: 11726557 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005478 decreased circulating thyroxine level PMID: 11731613 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0005478 decreased circulating thyroxine level PMID: 11159823 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv * C57BL/6
MGI:98742  MP:0005478 decreased circulating thyroxine level PMID: 12576486 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005479 decreased circulating triiodothyronine level PMID: 11731613 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0005479 decreased circulating triiodothyronine level PMID: 11726557 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005479 decreased circulating triiodothyronine level PMID: 11731613 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004437 decreased cochlear outer hair cell electromotility PMID: 11739587 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0000135 decreased cortical bone thickness PMID: 17327419 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0003910 decreased eating behavior PMID: 12869545 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004411 decreased endocochlear potential PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005130 decreased follicle stimulating hormone level PMID: 17210747 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005136 decreased growth hormone level PMID: 17210747 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0005333 decreased heart rate PMID: 11159823 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005333 decreased heart rate PMID: 12869545 
Thratm1Ven Thratm1Ven/Thratm1Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005333 decreased heart rate PMID: 9430637 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0005333 decreased heart rate PMID: 11159823 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0001935 decreased litter size PMID: 11734632 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005132 decreased luteinizing hormone level PMID: 17210747 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac
MGI:98742  MP:0004876 decreased mean systemic arterial blood pressure PMID: 15304375 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0004985 decreased osteoclast cell number PMID: 17327419 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005138 decreased prolactin level PMID: 17210747 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0008142 decreased small intestinal villus size PMID: 9927422 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0004953 decreased spleen weight PMID: 17622582 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0004852 decreased testis weight PMID: 17210747 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0003620 decreased urine output PMID: 12869545 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0005598 decreased ventricle muscle contractility PMID: 11159823 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0005598 decreased ventricle muscle contractility PMID: 11159823 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003409 decreased width of hypertrophic chondrocyte zone PMID: 17327419 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003409 decreased width of hypertrophic chondrocyte zone PMID: 16051666 
Tg(CAG-cre/Esr1*)5Amc|Thra+|Thratm1Ffla Tg(CAG-cre/Esr1*)5Amc/?,Thratm1Ffla/Thra+
involves: 129/Sv * C57BL/6 * CBA
MGI:2182765  MGI:98742  MP:0000060 delayed bone ossification PMID: 17622582 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0003419 delayed endochondral bone ossification PMID: 17327419 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003419 delayed endochondral bone ossification PMID: 16051666 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0003419 delayed endochondral bone ossification PMID: 17622582 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0001290 delayed eyelid opening PMID: 17622582 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0000422 delayed hair appearance PMID: 12869545 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004664 delayed inner ear development PMID: 11739587 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0000478 delayed intestine development PMID: 9927422 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0003420 delayed intramembranous bone ossification PMID: 16051666 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0010743 delayed suture closure PMID: 16051666 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0002427 disproportionate dwarf PMID: 17622582 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0001926 female infertility PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001926 female infertility PMID: 11739587 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0001926 female infertility PMID: 17622582 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0008033 impaired lipolysis PMID: 12869545 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003502 increased activity of thyroid PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003502 increased activity of thyroid PMID: 11731613 
Thra+|Thratm3Ven Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0001363 increased anxiety-related response PMID: 16131613 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005533 increased body temperature PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0005533 increased body temperature PMID: 11731613 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0001260 increased body weight PMID: 12869545 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0005605 increased bone mass PMID: 17327419 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0009347 increased cancellous bone thickness PMID: 17327419 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005559 increased circulating glucose level PMID: 12869545 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0002079 increased circulating insulin level PMID: 12869545 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005669 increased circulating leptin level PMID: 12869545 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12869545 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 11734632 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 15601836 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 9927422 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005477 increased circulating thyroxine level PMID: 12869545 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 15601836 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 9927422 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005477 increased circulating thyroxine level PMID: 12576486 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005480 increased circulating triiodothyronine level PMID: 12869545 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0005480 increased circulating triiodothyronine level PMID: 11734632 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 15601836 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005480 increased circulating triiodothyronine level PMID: 12576486 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0009288 increased epididymal fat pad weight PMID: 12869545 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0002626 increased heart rate PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0002626 increased heart rate PMID: 11731613 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0002626 increased heart rate PMID: 17622582 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0006398 increased long bone epiphyseal plate size PMID: 17327419 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005135 increased thyroid-stimulating hormone level PMID: 17210747 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0010024 increased total body fat amount PMID: 11731613 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0010024 increased total body fat amount PMID: 12869545 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0010024 increased total body fat amount PMID: 11731613 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0005474 increased triiodothyronine level PMID: 9927422 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0005331 insulin resistance PMID: 12869545 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0001636 irregular heartbeat PMID: 17622582 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001261 obese PMID: 11731613 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001261 obese PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0005422 osteosclerosis PMID: 17327419 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0002081 perinatal lethality PMID: 11731613 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001732 postnatal growth retardation PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0001732 postnatal growth retardation PMID: 17327419 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 11726557 
Thra+|Thratm2Ven|Thrbtm1Df Thratm2Ven/Thra+,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 11726557 
Thra+|Thratm2Ven Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001732 postnatal growth retardation PMID: 11731613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0001732 postnatal growth retardation PMID: 16051666 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0001732 postnatal growth retardation PMID: 17622582 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 9927422 
Thra+|Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thra+,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 9927422 
Thratm3Ven Thratm3Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl
MGI:98742  MP:0002082 postnatal lethality PMID: 12356724 
Thratm3Ven|Thrbtm1Df Thratm3Ven/Thratm3Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0002082 postnatal lethality PMID: 12356724 
Tg(Sycp1-cre)4Min|Thra+|Thratm1Ffla Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2
MGI:2176062  MGI:98742  MP:0002082 postnatal lethality PMID: 17622582 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0002083 premature death PMID: 11734632 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0002083 premature death PMID: 9927422 
Thratm1Brnt Thratm1Brnt/Thratm1Brnt
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0002080 prenatal lethality PMID: 12869545 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0009006 prolonged estrous cycle PMID: 11731613 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0010392 prolonged QRS complex duration PMID: 11159823 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0010392 prolonged QRS complex duration PMID: 11159823 
Thratm1Ven Thratm1Ven/Thratm1Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0003233 prolonged QT interval PMID: 9430637 
Thratm2Ven Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c
MGI:98742  MP:0001923 reduced female fertility PMID: 11731613 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0001923 reduced female fertility PMID: 11734632 
Thra+|Thratm1Brnt Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6
MGI:98742  MP:0001921 reduced fertility PMID: 12869545 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0001921 reduced fertility PMID: 11734632 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss
MGI:98742  MP:0001922 reduced male fertility PMID: 11734632 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0000547 short limbs PMID: 17327419 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0000592 short tail PMID: 17327419 
Thratm2Jas Thratm2Jas/Thratm2Jas
involves: 129/Sv
MGI:98742  MP:0002764 short tibia PMID: 17327419 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0002764 short tibia PMID: 16051666 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98742  MP:0004359 short ulna PMID: 16051666 
Thra+|Thratm1Syc Thratm1Syc/Thra+
involves: 129S6/SvEvTac
MGI:98742  MP:0002188 small heart PMID: 15304375 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005361 small pituitary gland PMID: 15601836 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0003498 thyroid gland hyperplasia PMID: 9927422 
Thratm1Jas Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ
MGI:98742  MP:0003499 thyroid hypoplasia PMID: 9927422 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hypothyroidism, congenital, nongoitrous, 6
OMIM:  614450
Orphanet:  97927
References: 
Mutations not determined
Biologically Significant Variants
Type:  Splice variant
Species:  Mouse
Description:  TRα3 : The carboxy proximal 39 amino acids of the TH-alpha-2 specific sequences are deleted in TR-alpha-3. Binds to DNA but not T3. Reported only from cDNA library.
References:  2,21
Type:  Splice variant
Species:  Human
Description:  TR-δ-α1: N-terminal truncated form of TRα 1: lacksT3 binding, shows no DNA binding and antagonises T3/retinoic acid induced transactivation activity.
References:  2
Type:  Splice variant
Species:  Human
Description:  TR-δ-α2: N-terminal truncated form of TRα 2: lacksT3 binding, shows no DNA binding and antagonises T3/retinoic acid induced transactivation activity.
References:  2
Type:  Splice variant
Species:  Human
Description:  Isoform TRα2 : Alternatively spliced carboxyl terminal. DNA binding but no T3 binding. Acts as antagonist
Amino acids:  490
Protein accession: 
References:  19,22
Type:  Splice variant
Species:  Rat
Description:  Isoform TRα2: includes alternate 3'-terminal exon, distinct C-terminus and lacks affinity to TRα1 hormones
Amino acids:  492
Protein accession: 

References

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How to cite this page

1A. Thyroid Hormone Receptors: Thyroid hormone receptor-α. Last modified on 17/03/2014. Accessed on 25/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=588.