dextrothyroxine

Ligand id: 6951

Name: dextrothyroxine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.78
Molecular weight 776.69
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1967))
IUPAC Name
(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
International Nonproprietary Names
INN number INN
1112 dextrothyroxine sodium
Synonyms
Choloxin® | D-T4 | D-thyroxine
Database Links
CAS Registry No. 51-49-0
ChEBI CHEBI:30659
ChEMBL Ligand CHEMBL559
DrugBank Ligand DB00509
PubChem CID 8730
Search Google for chemical match using the InChIKey XUIIKFGFIJCVMT-GFCCVEGCSA-N
Search Google for chemicals with the same backbone XUIIKFGFIJCVMT
Search PubMed clinical trials dextrothyroxine sodium
Search PubMed titles dextrothyroxine sodium
Search PubMed titles/abstracts dextrothyroxine sodium
Search UniChem for chemical match using the InChIKey XUIIKFGFIJCVMT-GFCCVEGCSA-N
Search UniChem for chemicals with the same backbone XUIIKFGFIJCVMT
Wikipedia Dextrothyroxine
Comments
The INN record for this compound and the US FDA approval, are for the sodium salt. This drug is the dextrorotary isomer of synthetic thyroxine and acts as an antihyperlipidemic.