atglistatin [Ligand Id: 12995] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3823931 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| patatin like phospholipase domain containing 2/Patatin-like phospholipase domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3822353] [GtoPdb: 3253] [UniProtKB: Q96AD5] | ||||||||
| GtoPdb | - | - | 6.15 | pIC50 | 700 | nM | IC50 | Nat Chem Biol (2013) 9: 785-7 [PMID:24096302] |
| ChEMBL | Inhibition of ATGL (unknown origin) overexpressed in Escherichia coli XL-1 cells using [9,10-3H(N)]triolein as substrate incubated for 60 mins by liquid scintillation counting method | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2016) 118: 290-298 [PMID:27155760] |
| Patatin-like phospholipase domain-containing protein 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3425391] [UniProtKB: Q8BJ56] | ||||||||
| ChEMBL | Inhibition of murine ATGL expressed in COS-7 cells | B | 5.3 | pIC50 | <5000 | nM | IC50 | Bioorg Med Chem (2020) 28: 115610-115610 [PMID:32690265] |
| ChEMBL | Inhibition of recombinant murine ATGL expressed in Escherichia coli XL-1 lysates | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem (2020) 28: 115610-115610 [PMID:32690265] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
