ChEMBL ligand: CHEMBL316446 (Endomorphin 1)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]DPDPE from Myc-tagged delta opioid receptor expressed in HEK293 cells after 60 mins by liquid scintillation counter	B	5.22	pKi	6080	nM	Ki	J Med Chem (2012) 55: 6224-6236 [PMID:22724433]
ChEMBL	Displacement of [3H]-DPDPE from delta opioid receptor (unknown origin) transfected in HEK293 cells	B	5.22	pKi	6080	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5393-5397 [PMID:26403932]
ChEMBL	Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cell membranes	B	5.29	pKi	5100	nM	Ki	Bioorg Med Chem Lett (2013) 23: 3434-3437 [PMID:23623418]
ChEMBL	Displacement of [3H]DPDPE from delta-opioid receptor expressed in CHOK1 cells after overnight incubation by scintillation proximity assay	B	5.56	pKi	2765	nM	Ki	J Med Chem (2012) 55: 5859-5867 [PMID:22680612]
ChEMBL	Displacement of [3H]DPDPE from DOP receptor expressed in CHO-K1 cells after overnight incubation by beta counting method	B	5.56	pKi	2765	nM	Ki	Bioorg Med Chem (2012) 20: 6335-6343 [PMID:23022277]
GtoPdb	-	-	6.1	pKi	-	-	-	FEBS Lett (1998) 439: 152-6 [PMID:9849897]
ChEMBL	Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay	F	6.03	pEC50	932	nM	EC50	J Med Chem (2007) 50: 512-520 [PMID:17266203]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically evoked muscle contractions	F	6.55	pIC50	283	nM	IC50	Bioorg Med Chem (2007) 15: 1237-1251 [PMID:17142049]
ChEMBL	Agonist activity at delta opioid receptor in Kunming mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction	F	7.52	pIC50	30.4	nM	IC50	J Med Chem (2012) 55: 6224-6236 [PMID:22724433]
ChEMBL	Agonist activity at delta opioid receptor by inhibition of electrically evoked muscle contraction in isolated mouse vas deferens	F	7.58	pIC50	26.3	nM	IC50	J Med Chem (2007) 50: 512-520 [PMID:17266203]
ChEMBL	Inhibition of delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction	B	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3434-3437 [PMID:23623418]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Displacement of [3H]-DPDPE from Wistar rat delta opioid receptor incubated for 3 hrs by liquid scintillation counting method	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2020) 28: 115438-115438 [PMID:32199689]
ChEMBL	Displacement of [3H]Ile5,6-deltorphin II from opioid receptor delta 1 of rat brain membranes	B	5.19	pKi	6390	nM	Ki	J Med Chem (2004) 47: 735-743 [PMID:14736254]
ChEMBL	Displacement of [3H]DPDPE from DOR in Wistar rat brain membranes measured after 3 hrs by scintillation counting method	B	5.21	pKi	6105	nM	Ki	J Med Chem (2021) 64: 16801-16819 [PMID:34781680]
ChEMBL	Displacement of [3H]DPDPE from delta-opioid receptor in Wistar rat brain membrane after 3 hrs by microbeta scintillation counting method	B	5.24	pKi	5775	nM	Ki	Bioorg Med Chem Lett (2017) 27: 2119-2123 [PMID:28377055]
ChEMBL	Displacement of [3H]-DPDPE from delta opioid receptor in Wistar rat brain membranes preincubated for 3 hrs measured after 1 hr by scintillation counting method	B	5.29	pKi	5093	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1557-1560 [PMID:28256374]
ChEMBL	Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membrane homogenate by liquid scintillation counting	B	5.38	pKi	4169	nM	Ki	J Med Chem (2011) 54: 1462-1472 [PMID:21287991]
ChEMBL	Displacement of [3H]Ile5,6deltorphin-2 from delta opioid receptor in Wistar rat brain	B	5.72	pKi	1909	nM	Ki	J Med Chem (2008) 51: 4270-4279 [PMID:18572932]
ChEMBL	Displacement of [3H]deltorphin 2 from delta opioid receptor in rat brain P2 synaptosome	B	5.76	pKi	1750	nM	Ki	Bioorg Med Chem (2007) 15: 1237-1251 [PMID:17142049]
ChEMBL	Displacement of [3H]DAMGO from delta opioid receptor in rat brain membrane	B	5.89	pKi	1280	nM	Ki	Bioorg Med Chem (2008) 16: 6286-6296 [PMID:18468445]
ChEMBL	Displacement of [3H]DPDPE from rat cortex delta opioid receptor after 2.5 hrs by liquid scintillation counting analysis	B	6.14	pKi	729	nM	Ki	Eur J Med Chem (2015) 92: 270-281 [PMID:25559207]
ChEMBL	Displacement of [3H]DPDPE from rat cortical DOR after 2.5 hrs by liquid scintillation counting method	B	6.24	pKi	575	nM	Ki	J Med Chem (2016) 59: 1239-1245 [PMID:26789491]
ChEMBL	Displacement of [3H]deltorphin2 from delta opioid receptor in rat brain membrane	B	5.45	pIC50	3580	nM	IC50	Bioorg Med Chem (2007) 15: 3883-3888 [PMID:17395470]
ChEMBL	Displacement of [3H][Ile5,6]deltorphin-2 from delta opioid receptor in Wistar rat brain membrane	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem (2009) 17: 3789-3794 [PMID:19435668]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from kappa-opioid receptor expressed in CHOK1 cells after overnight incubation by scintillation proximity assay	B	5.69	pKi	2048	nM	Ki	J Med Chem (2012) 55: 5859-5867 [PMID:22680612]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Displacement of[3H]-U69,593 from Wistar rat kappa opioid receptor incubated for 1.5 hrs by liquid scintillation counting method	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2020) 28: 115438-115438 [PMID:32199689]
ChEMBL	Displacement of [3H]-U69593 from KOR in Wistar rat brain membranes measured after 1 hr by scintillation counting method	B	5	pKi	>10000	nM	Ki	J Med Chem (2021) 64: 16801-16819 [PMID:34781680]
ChEMBL	Displacement of [3H]dynorphin A from Opioid receptor kappa 1 of rat brain membranes (DAMGO/DADLE quenching of mu/delta receptor binding)	B	7.28	pKi	52.7	nM	Ki	J Med Chem (2004) 47: 735-743 [PMID:14736254]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Displacement of [3H]U69,593 from guinea pig KOR after 2 hrs by liquid scintillation counting method	B	5.3	pKi	5069	nM	Ki	J Med Chem (2016) 59: 1239-1245 [PMID:26789491]
ChEMBL	Displacement of [3H]U69,593 from guinea pig cortex/cerebella kappa opioid receptor after 2 hrs by liquid scintillation counting analysis	B	5.63	pKi	2354	nM	Ki	Eur J Med Chem (2015) 92: 270-281 [PMID:25559207]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	-	-	8.3	pKi	5.01	nM	Ki	FEBS Lett (1998) 439: 152-6 [PMID:9849897]; Nature (1997) 386: 499-502 [PMID:9087409]
ChEMBL	Binding affinity to human mu opioid receptor	B	8.34	pKi	4.55	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5387-5391 [PMID:19679474]
ChEMBL	Displacement of [3H]-DAMGO from mu opioid receptor (unknown origin) transfected in HEK293 cells	B	8.59	pKi	2.6	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5393-5397 [PMID:26403932]
ChEMBL	Displacement of [3H]DAMGO from FLAG-tagged mu opioid receptor expressed in HEK293 cells after 60 mins by liquid scintillation counter	B	8.59	pKi	2.6	nM	Ki	J Med Chem (2012) 55: 6224-6236 [PMID:22724433]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in human SH-SY5Y cells	B	8.84	pKi	1.45	nM	Ki	Bioorg Med Chem (2008) 16: 4341-4346 [PMID:18329886]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in human SHSY5Y cells	B	8.95	pKi	1.11	nM	Ki	Bioorg Med Chem (2008) 16: 6286-6296 [PMID:18468445]
ChEMBL	Displacement of [3H]DAMGO from MOP receptor expressed in CHO-K1 cells after overnight incubation by beta counting method	B	9.12	pKi	0.76	nM	Ki	Bioorg Med Chem (2012) 20: 6335-6343 [PMID:23022277]
ChEMBL	Displacement of [3H]DAMGO from mu-opioid receptor expressed in CHOK1 cells after overnight incubation by scintillation proximity assay	B	9.54	pKi	0.29	nM	Ki	J Med Chem (2012) 55: 5859-5867 [PMID:22680612]
ChEMBL	Agonist activity at mu-opioid receptor in human SH-SY5Y cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by immunoassay	F	7.18	pIC50	65.4	nM	IC50	J Med Chem (2012) 55: 5859-5867 [PMID:22680612]
ChEMBL	Agonist activity at mu opioid receptor in human SHSY5Y cells assessed as inhibition of forskolin-stimulated cAMP production	F	7.85	pIC50	14	nM	IC50	Bioorg Med Chem (2008) 16: 6286-6296 [PMID:18468445]
ChEMBL	Agonist activity at MOP receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins	F	8.49	pIC50	3.2	nM	IC50	Bioorg Med Chem (2012) 20: 6335-6343 [PMID:23022277]
ChEMBL	Agonist activity at mu opioid receptor (unknown origin) expressed in human HEK293 cells assessed as increase in cAMP accumulation using [3H]-cAMP as substrate measured after 30mins by liquid scintillation counting method	F	7.21	pEC50	61	nM	EC50	Bioorg Med Chem (2020) 28: 115438-115438 [PMID:32199689]
ChEMBL	Agonist activity at mu-opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 15 mins by ELISA	F	7.68	pEC50	21.1	nM	EC50	J Med Chem (2021) 64: 16801-16819 [PMID:34781680]
ChEMBL	Agonist activity at mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by liquid scintillation counter	F	7.84	pEC50	14.4	nM	EC50	J Med Chem (2012) 55: 6224-6236 [PMID:22724433]
ChEMBL	Agonist activity at mu opioid receptor (unknown origin) transfected in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production	F	7.84	pEC50	14.4	nM	EC50	Bioorg Med Chem Lett (2015) 25: 5393-5397 [PMID:26403932]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Inhibition of Mu opioid receptor of mouse vas deferens	B	7.44	pIC50	36.3	nM	IC50	J Med Chem (2004) 47: 735-743 [PMID:14736254]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Displacement of [3H]-DAMGO from Wistar rat mu opioid receptor incubated for 1 hr by liquid scintillation counting method	B	7.75	pKi	17.8	nM	Ki	Bioorg Med Chem (2020) 28: 115438-115438 [PMID:32199689]
ChEMBL	Binding affinity towards Opioid receptor mu 1	B	7.95	pKi	11.1	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2755-2758 [PMID:11133084]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane by liquid scintillation counting	B	7.97	pKi	10.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4115-4118 [PMID:19560919]
ChEMBL	Displacement of [3H]DAMGO from mu-opioid receptor in Wistar rat brain membrane after 1 hr by microbeta scintillation counting method	B	8.21	pKi	6.19	nM	Ki	Bioorg Med Chem Lett (2017) 27: 2119-2123 [PMID:28377055]
ChEMBL	Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes measured after 1 hr by scintillation counting method	B	8.33	pKi	4.63	nM	Ki	J Med Chem (2021) 64: 16801-16819 [PMID:34781680]
ChEMBL	Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cell membranes	B	8.34	pKi	4.6	nM	Ki	Bioorg Med Chem Lett (2013) 23: 3434-3437 [PMID:23623418]
ChEMBL	Displacement of [3H]-DAMGO from mu opioid receptor in Wistar rat brain membranes preincubated for 1 hr measured after 1hr by scintillation counting method	B	8.34	pKi	4.53	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1557-1560 [PMID:28256374]
ChEMBL	Displacement of [3H]DAMGO from Opioid receptor mu 1 of rat brain membranes	B	8.38	pKi	4.21	nM	Ki	J Med Chem (2004) 47: 735-743 [PMID:14736254]
ChEMBL	Displacement of [3H]DAMGO from rat cortex mu opioid receptor after 30 mins by liquid scintillation counting analysis	B	8.4	pKi	4	nM	Ki	Eur J Med Chem (2015) 92: 270-281 [PMID:25559207]
ChEMBL	Displacement of [3H]endomorphin-2 from mu opioid receptor in Wistar rat brain	B	8.68	pKi	2.1	nM	Ki	J Med Chem (2008) 51: 4270-4279 [PMID:18572932]
ChEMBL	Displacement of [3H]endomorphin-2 from Opioid receptor mu 1 of rat brain membranes	B	8.79	pKi	1.62	nM	Ki	J Med Chem (2004) 47: 735-743 [PMID:14736254]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane homogenate by liquid scintillation counting	B	8.8	pKi	1.6	nM	Ki	J Med Chem (2011) 54: 1462-1472 [PMID:21287991]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane	B	8.94	pKi	1.15	nM	Ki	Bioorg Med Chem (2008) 16: 6286-6296 [PMID:18468445]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain	B	9.13	pKi	0.74	nM	Ki	J Med Chem (2008) 51: 4270-4279 [PMID:18572932]
ChEMBL	Displacement of [3H]DAMGO from rat cortical MOR by liquid scintillation counting method	B	9.15	pKi	0.7	nM	Ki	J Med Chem (2016) 59: 1239-1245 [PMID:26789491]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat brain P2 synaptosome	B	9.25	pKi	0.56	nM	Ki	Bioorg Med Chem (2007) 15: 1237-1251 [PMID:17142049]
ChEMBL	Binding affinity towards Opioid receptor mu 1 by displacing [3H]DAMGO in rat brain membranes.	B	9.8	pKi	0.16	nM	Ki	J Med Chem (2002) 45: 2571-2578 [PMID:12036366]
ChEMBL	Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranes	B	9.8	pKi	0.16	nM	Ki	J Med Chem (2004) 47: 5198-5203 [PMID:15456262]
ChEMBL	Concentration required for inhibition of [3H]DAMGO binding to Opioid receptor mu 1 in rat brain membranes	B	7.25	pIC50	56	nM	IC50	Bioorg Med Chem Lett (2000) 10: 2755-2758 [PMID:11133084]
ChEMBL	Displacement of [3H]DAGO from mu opioid receptor in rat brain membrane	B	8.72	pIC50	1.89	nM	IC50	Bioorg Med Chem (2007) 15: 3883-3888 [PMID:17395470]
ChEMBL	Inhibitory activity against [3H]DAMGO binding to Opioid receptor mu 1 in rat brain membranes	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2002) 45: 2571-2578 [PMID:12036366]
ChEMBL	Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain membranes	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2004) 47: 5198-5203 [PMID:15456262]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain membrane	B	9.37	pIC50	0.43	nM	IC50	Bioorg Med Chem (2009) 17: 3789-3794 [PMID:19435668]
ChEMBL	Agonist activity at mu opioid receptor in rat brain membrane by [35S]GTPgammaS binding assay	F	6.78	pEC50	166	nM	EC50	J Med Chem (2011) 54: 1462-1472 [PMID:21287991]
ChEMBL	Activity at mu opioid receptor in Wistar rat brain assessed as stimulation of [35S]GTPgammaS binding	F	6.98	pEC50	104	nM	EC50	J Med Chem (2008) 51: 4270-4279 [PMID:18572932]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated contraction	F	4.55	pIC50	28000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4115-4118 [PMID:19560919]
ChEMBL	Agonist activity at mu opioid receptor by inhibition of electrically evoked muscle contraction in guinea pig ileum	F	7.76	pIC50	17.2	nM	IC50	J Med Chem (2007) 50: 512-520 [PMID:17266203]
ChEMBL	Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction	F	7.85	pIC50	14.1	nM	IC50	J Med Chem (2012) 55: 6224-6236 [PMID:22724433]
ChEMBL	Inhibition of mu opioid receptor in guinea pig ileum/longitudinal muscle with myenteric plexus assessed as inhibition of electrically-stimulated muscle contraction	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3434-3437 [PMID:23623418]
ChEMBL	Inhibition of Opioid receptor mu 1 of guinea pig ileum	B	8	pIC50	10.1	nM	IC50	J Med Chem (2004) 47: 735-743 [PMID:14736254]
ChEMBL	Agonist activity at mu opioid receptor in Hartley guinea pig intestine assessed as inhibition of electrically evoked myenteric plexus longitudinal muscle contractions	F	8.39	pIC50	4.03	nM	IC50	Bioorg Med Chem (2007) 15: 1237-1251 [PMID:17142049]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]