GR 89696 [Ligand Id: 1649] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL603370 (GR-89696) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | In vitro inhibitory activity against delta specific tissue of hamster vas deferens | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1993) 36: 2075-2083 [PMID:8393489] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Binding affinity to kappa opioid receptor (unknown origin) | B | 6.44 | pKi | 360 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5326-5330 [PMID:26411794] |
| ChEMBL | Displacement of [3H]U69593 from kappa opioid receptor | B | 9.35 | pKi | 0.45 | nM | Ki | Eur J Med Chem (2011) 46: 1972-1982 [PMID:21481987] |
| GtoPdb | - | - | 9.7 | pKi | - | - | - | Nucl Med Biol (2002) 29: 47-53 [PMID:11786275] |
| ChEMBL | In vitro agonist activity at kappa opioid receptor in rabbit vas deferens. | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (1993) 36: 2075-2083 [PMID:8393489] |
| ChEMBL | In vitro agonist activity at kappa opioid receptor in rabbit vas deferens. | F | 10.39 | pIC50 | 0.04 | nM | IC50 | J Med Chem (1993) 36: 2075-2083 [PMID:8393489] |
| ChEMBL | In vitro agonist activity at kappa opioid receptor in rabbit vas deferens. | F | 10.74 | pIC50 | 0.02 | nM | IC50 | J Med Chem (1993) 36: 2075-2083 [PMID:8393489] |
| Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
| ChEMBL | Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting | B | 9.44 | pKi | 0.36 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5326-5330 [PMID:26411794] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Displacement of [(3)H]U69593 from mu opioid receptor | B | 9.44 | pKi | 0.36 | nM | Ki | J Med Chem (2010) 53: 4212-4222 [PMID:20441176] |
| μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
| ChEMBL | In vitro inhibitory activity against mu specific tissue of rat vas deferens | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1993) 36: 2075-2083 [PMID:8393489] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
