L742791 [Ligand Id: 3467] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL276257 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Evaluated for its agonist activity and the binding affinity against human Beta-1 adrenergic receptor in membranes from chinese hamster ovary cell | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496] |
| ChEMBL | Tested for binding affinity against cloned human beta-1 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| ChEMBL | Compound was tested for agonist activity against cloned human beta-1 adrenergic receptor | F | 6.49 | pEC50 | 320 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Evaluated for its agonist activity and the binding affinity against human Beta-2 adrenergic receptor in membranes from chinese hamster ovary cell | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496] |
| ChEMBL | Binding affinity against cloned human beta-2 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| ChEMBL | Evaluated for its agonist activity against human Beta-3 adrenergic receptor | F | 8.8 | pEC50 | 1.6 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496] |
| ChEMBL | Agonist activity against cloned human beta-3 adrenergic receptor | F | 8.8 | pEC50 | 1.6 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| GtoPdb | - | - | 8.8 | pEC50 | 1.6 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 2111-6 [PMID:9873496] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
