flavanone [Ligand Id: 408] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL274318 (NSC-50393) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. | B | 4.49 | pKi | 32000 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| GtoPdb | - | - | 4.5 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 4.3 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| ChEMBL | Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. | B | 4.3 | pKi | 50100 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay | F | 4.7 | pIC50 | 20000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4706-4710 [PMID:19592245] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 4.26 | pIC50 | 54954.09 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1 | B | 4.55 | pIC50 | 28500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 1059-1061 [PMID:11909717] |
| ChEMBL | Inhibition of human aromatase in placental microsomes | B | 4.55 | pIC50 | 28000 | nM | IC50 | Bioorg Med Chem (2008) 16: 1474-1480 [PMID:18042388] |
| ChEMBL | Inhibition of aromatase (unknown origin) | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2014) 22: 126-134 [PMID:24345481] |
| ChEMBL | Inhibition of aromatase (unknown origin) | B | 5.1 | pIC50 | 8000 | nM | IC50 | Eur J Med Chem (2015) 102: 375-386 [PMID:26301554] |
| Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
| ChEMBL | Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay | B | 5.54 | pIC50 | 2870 | nM | IC50 | Bioorg Med Chem (2010) 18: 1273-1279 [PMID:20045650] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
