ChEMBL ligand: CHEMBL173031 (LY-233053, LY-235723)
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL	Tested in vitro for the affinity against NMDA receptor in a cortical wedge assay	B	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem Lett (1993) 3: 43-48
ChEMBL	Tested in vitro for the affinity against NMDA receptor by examining its ability to inhibit [3H]-CGS-19,755 binding	B	6.97	pIC50	107	nM	IC50	Bioorg Med Chem Lett (1993) 3: 43-48
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL	Compound was tested for the antagonistic activity against depolarizations due to NMDA using rat cortical slice preparation	F	4.38	pIC50	42000	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was tested for the antagonistic activity against depolarizations due to NMDA using rat cortical slice preparation	F	4.41	pIC50	39100	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was evaluated in vitro in a cortical-wedge preparation for the antagonism of N-methyl-D-aspartate-induced responses	F	5.38	pIC50	4200	nM	IC50	J Med Chem (1991) 34: 90-97 [PMID:1825117]
ChEMBL	Compound was tested in vitro for its ability to inhibit depolarizations induced by 40 uM NMDA in a cortical slice (NMDA antagonist)	F	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem Lett (1998) 8: 389-394 [PMID:9871691]
ChEMBL	Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor	B	5.62	pIC50	2393	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was tested for the antagonistic activity against depolarizations due to NMDA using rat cortical slice preparation	F	5.72	pIC50	1900	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor	B	6.97	pIC50	107	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	In vitro binding affinity against N-methyl-D-aspartate glutamate receptor using [3H]CGS-19,755 ligand	B	6.97	pIC50	107	nM	IC50	J Med Chem (1991) 34: 90-97 [PMID:1825117]
ChEMBL	In vitro compound's ability to displace [3H]-CGS-19,755 binding as a measure of its affinity for the glutamate recognition site on the NMDA receptor complex.	B	6.97	pIC50	107	nM	IC50	J Med Chem (1992) 35: 3547-3560 [PMID:1404235]
ChEMBL	Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor	B	7.17	pIC50	67	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was tested in vitro for inhibition of binding of [3H]-CGS- 19755 radioligand to NMDA receptor in rat brain membranes	B	7.77	pIC50	17	nM	IC50	Bioorg Med Chem Lett (1998) 8: 389-394 [PMID:9871691]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]