GluN2D

Nomenclature: GluN2D

Family: Ionotropic glutamate receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 1 1336 19q13.1 GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Mouse 3 1 1323 7 B4 Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Rat 3 1 1323 1q22 Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Previous and Unofficial Names
GLUN2D
NMDA-R2D
NR2D
GluRε4
NMDAR2D
EB11
N-methyl-d-aspartate receptor subunit 2D
Glutamate receptor ionotropic N-methyl D-aspartate 2D
Glutamate receptor, ionotropic, N-methyl D-aspartate 2D
N-methyl D-aspartate receptor subtype 2D
glutamate [NMDA] receptor subunit epsilon-4
glutamate receptor, ionotropic, NMDA2D
GluRepsilon4
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
L-glutamic acid
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
D-aspartate Hs Agonist - -
[Binds to: glutamate site] GluN2D > GluN2C = GluN2B > GluN2A
homoquinolinic acid Hs Full agonist - -
[Binds to: glutamate site] GluN2B ≥ GluN2A ≥ GluN2D > GluN2C; partial agonist at GluN2A and GluN2C
glycine Hs Agonist - -
[Binds to: glycine site] GluN2D > GluN2C > GluN2B > GluN2A
D-serine Hs Agonist - -
[Binds to: glycine site] GluN2D > GluN2C > GluN2B > GluN2A
[3H]glycine Hs Agonist - -
[Binds to: glycine site]
NMDA Hs Full agonist - -
[Binds to: glutamate site] GluN2D > GluN2C > GluN2B > GluN2A
(RS)-(tetrazol-5-yl)glycine Hs Full agonist - -
[Binds to: glutamate site] GluN2D > GluN2C = GluN2B > GluN2A
L-aspartate Hs Agonist - -
[Binds to: glutamate site] GluN2D = GluN2B > GluN2C = GluN2A
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
UBP141 Hs Antagonist - - 1
[Binds to: glutamate site] GluN2D ≥ GluN2C > GluN2A ≥ GluN2B [1]
LY233053 Hs Antagonist - -
[Binds to: glutamate site]
selfotel Hs Antagonist - -
[Binds to: glutamate site]
CGP37849 Hs Antagonist - -
[Binds to: glutamate site]
L701324 Hs Antagonist - -
[Binds to: glycine site]
conantokin-G Hs Antagonist - -
[Binds to: glutamate site] GluN2B > GluN2D = GluN2C = GluN2A
d-CCPene Hs Antagonist - -
[Binds to: glutamate site] GluN2A = GluN2B > GluN2C = GluN2D
[3H]CGP39653 Hs Antagonist - -
[Binds to: glutamate site]
d-AP5 Hs Antagonist - -
[Binds to: glutamate site]
[3H]CGP61594 Hs Antagonist - -
[Binds to: glycine site] [3H]CGP61594 is a photoaffinity ligand
GV196771A Hs Antagonist - -
[Binds to: glycine site]
[3H]CGS19755 Hs Antagonist - -
[Binds to: glutamate site]
[3H]CPP Hs Antagonist - -
[Binds to: glutamate site]
L689560 Hs Antagonist - -
[Binds to: glycine site]
[3H]MDL105519 Hs Antagonist - -
[Binds to: glycine site]
5,7-dichlorokynurenic acid Hs Antagonist - -
[Binds to: glycine site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
memantine Hs - no - - - no
GluN2C ≥ GluN2D ≥ GluN2B > GluN2A
Not voltage dependent
dizocilpine Hs - no - - - no

Not voltage dependent
phencyclidine Hs - no - - - no

Not voltage dependent
Mg2+ Hs - no - - - no
GluN2A = GluN2B > GluN2C = GluN2D
Not voltage dependent
[3H]L689560 Hs - no - - - no
[Binds to: glycine site]
Not voltage dependent
amantidine Hs - no - - - no
GluN2C = GluN2D ≥ GluN2B ≥ GluN2A
Not voltage dependent
[3H]MK-801 Hs - no - - - no
[Binds to: cation channel]
Not voltage dependent
N1-dansyl-spermine Hs - no - - - no
GluN2A = GluN2B >> GluN2C = GluN2D
Not voltage dependent
ketamine Hs - no - - - no

Not voltage dependent

References

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1. Morley RM, Tse HW, Feng B, Miller JC, Monaghan DT, Jane DE. (2005) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J. Med. Chem.48 (7): 2627-37. [PMID:15801853]

How to cite this page

John A. Peters, Stephane Peineau, Graham L Collingridge, Robert J. Wenthold.
Ionotropic glutamate receptors: GluN2D. Last modified on 14/03/2014. Accessed on 02/09/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459.