benzylcysteine [Ligand Id: 4501] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL63130 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Asc-type amino acid transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105976] [GtoPdb: 901] [UniProtKB: P63116] | ||||||||
| ChEMBL | Inhibition of asc-1 mediated [3H]-D-serine uptake in P2 fraction of rat forebrain synaptosomes after 4 mins by beta scintillation counting | B | 4.07 | pIC50 | 86000 | nM | IC50 | US-8741955-B2. D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders (null) |
| kinesin-5/Kinesin-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4581] [GtoPdb: 2788] [UniProtKB: P52732] | ||||||||
| ChEMBL | Inhibition of Eg5 assessed as inhibition ATP hydrolysis by ATPase assay | F | 4.2 | pIC50 | >63000 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3921-3924 [PMID:17524640] |
| Alanine/serine/cysteine transporter 2 in Human [GtoPdb: 874] [UniProtKB: Q15758] | ||||||||
| GtoPdb | - | - | 3.11 | pKi | 780000 | nM | Ki | J Physiol (Lond.) (2004) 557: 747-59 [PMID:15107471] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
