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ChEMBL ligand: CHEMBL247378 (7-Nitroindazole) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | Br J Pharmacol (1993) 110: 225-8 [PMID:7693279] |
ChEMBL | Inhibitory activity against human neuronal nitric oxide synthase (nNOS) | B | 5.54 | pIC50 | 2870 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2569-2572 [PMID:10498210] |
ChEMBL | In vitro inhibition of human neuronal nitric oxide synthase | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2004) 47: 1575-1586 [PMID:14998342] |
ChEMBL | Inhibition of NOS1 | B | 6.15 | pIC50 | 710 | nM | IC50 | Bioorg Med Chem (2009) 17: 6180-6187 [PMID:19679481] |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | Inhibition of rat recombinant nNOS expressed in Saccharomyces cerevisiae assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactive assay | B | 4.57 | pIC50 | 27000 | nM | IC50 | Eur J Med Chem (2009) 44: 2877-2887 [PMID:19144449] |
ChEMBL | Inhibition of rat brain recombinant nNOS | B | 4.6 | pIC50 | 25000 | nM | IC50 | Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134] |
ChEMBL | Inhibitory activity against rat neuronal nitric oxide synthase (nNOS) | B | 5.67 | pIC50 | 2120 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2569-2572 [PMID:10498210] |
ChEMBL | Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by neuronal NOS from rat cerebellum. | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 1573-1576 |
ChEMBL | In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthase | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1153-1156 [PMID:11354365] |
ChEMBL | Inhibition of rat neuronal NOS | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3177-3180 [PMID:17395463] |
ChEMBL | Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visible spectrophotometer analysis | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem (2011) 19: 3935-3944 [PMID:21665485] |
Endothelial NOS/Nitric oxide synthase, endothelial in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075230] [GtoPdb: 1249] [UniProtKB: Q62600] | ||||||||
ChEMBL | Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 mins | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2019) 168: 491-514 [PMID:30851693] |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
ChEMBL | Tested to inhibit the conversion of [3H]-L-arginine to [3H]L-citrulline catalyzed by endothelial NOS from human umbilical vein endothelial cells. | B | 4.44 | pIC50 | 36000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 1573-1576 |
ChEMBL | In vitro inhibition of human endothelial nitric oxide synthase | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2004) 47: 1575-1586 [PMID:14998342] |
ChEMBL | Inhibitory activity against human endothelial nitric oxide synthase (eNOS) | B | 5.72 | pIC50 | 1890 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2569-2572 [PMID:10498210] |
Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
ChEMBL | Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactive assay | B | 4.39 | pIC50 | 41000 | nM | IC50 | Eur J Med Chem (2009) 44: 2877-2887 [PMID:19144449] |
ChEMBL | Inhibition of bovine recombinant eNOS | B | 4.46 | pIC50 | 35000 | nM | IC50 | Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
ChEMBL | Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells. | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 1573-1576 |
ChEMBL | Inhibition of NOS2 | B | 5.24 | pIC50 | 5800 | nM | IC50 | Bioorg Med Chem (2009) 17: 6180-6187 [PMID:19679481] |
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
ChEMBL | Inhibition of mouse recombinant iNOS | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134] |
ChEMBL | Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactive assay | B | 4.4 | pIC50 | 40000 | nM | IC50 | Eur J Med Chem (2009) 44: 2877-2887 [PMID:19144449] |
ChEMBL | Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells | B | 4.7 | pIC50 | 20000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 1573-1576 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]