PIBTU [Ligand Id: 5246] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL107201 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
| ChEMBL | Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline | B | 6.6 | pKi | 250 | nM | Ki | Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512] |
| Inducible NOS in Human [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| GtoPdb | - | - | 7.3 | pIC50 | 50.1 | nM | IC50 | J Biol Chem (1994) 269: 26669-76 [PMID:7523409] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
