ChEMBL ligand: CHEMBL474991 (WAY-207024)
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Human [ChEMBL: CHEMBL1855] [GtoPdb: 256] [UniProtKB: P30968] GnRH1 receptor/Gonadotropin-releasing hormone receptor in Rat [ChEMBL: CHEMBL3066] [GtoPdb: 256] [UniProtKB: P30969] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] There should be some charts here, you may need to enable JavaScript!
NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1855] [GtoPdb: 256] [UniProtKB: P30968]
ChEMBL	Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reduction	F	7.55	pIC50	28	nM	IC50	J Med Chem (2009) 52: 2148-2152 [PMID:19271735]
ChEMBL	Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration assay	F	7.55	pIC50	28	nM	IC50	Bioorg Med Chem Lett (2010) 20: 2512-2515 [PMID:20236823]
GtoPdb	-	-	7.92	pIC50	12	nM	IC50	J Med Chem (2009) 52: 2148-52 [PMID:19271735]
ChEMBL	Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptor	B	7.92	pIC50	12	nM	IC50	J Med Chem (2009) 52: 2148-2152 [PMID:19271735]
ChEMBL	Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation counting	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2010) 20: 2512-2515 [PMID:20236823]
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3066] [GtoPdb: 256] [UniProtKB: P30969]
ChEMBL	Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibition of D-Trp6-GnRH-induced LH accumulation after 3 hrs by RIA	F	6.44	pIC50	360	nM	IC50	Bioorg Med Chem Lett (2010) 20: 2512-2515 [PMID:20236823]
ChEMBL	Antagonist activity at rat recombinant GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated LH release from rat pituitary cells	F	6.49	pIC50	320	nM	IC50	J Med Chem (2009) 52: 2148-2152 [PMID:19271735]
ChEMBL	Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation counting	B	7.14	pIC50	72	nM	IC50	Bioorg Med Chem Lett (2010) 20: 2512-2515 [PMID:20236823]
ChEMBL	Displacement of [D-Trp6]-GnRH from rat recombinant GnRH receptor	B	7.15	pIC50	71	nM	IC50	J Med Chem (2009) 52: 2148-2152 [PMID:19271735]
GtoPdb	-	-	7.15	pIC50	71	nM	IC50	J Med Chem (2009) 52: 2148-52 [PMID:19271735]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	Inhibition of human histamine H2 receptor	B	6.07	pKi	850	nM	Ki	J Med Chem (2009) 52: 2148-2152 [PMID:19271735]
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL	Inhibition of human neurokinin NK2 receptor	B	6.48	pKi	330	nM	Ki	J Med Chem (2009) 52: 2148-2152 [PMID:19271735]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]