PI1 [Ligand Id: 5814] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1801361 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Inhibition of CB1 receptor | B | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693] |
| NPS receptor/Neuropeptide S receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4] | ||||||||
| GtoPdb | - | - | 7.3 | pIC50 | - | - | - | Bioorg Med Chem Lett (2010) 20: 4704-8 [PMID:20615693] |
| ChEMBL | Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay | F | 7.37 | pIC50 | 43 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693] |
| ChEMBL | Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay | F | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2013) 56: 9045-9056 [PMID:24171469] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
