MF 498 [Ligand Id: 5856] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL402162
  • DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
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  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
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  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
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  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
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  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
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  • FP receptor/Prostanoid FP receptor in Human [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL Binding affinity to human DP receptor expressed in HEK293 cells B 5.92 pKi 1200 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Binding affinity to human EP1 receptor expressed in HEK293 cells B 5.15 pKi >7000 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Binding affinity to human EP2 receptor expressed in HEK293 cells B 5.72 pKi 1900 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Binding affinity to human EP3 receptor expressed in HEK293 cells B 5.4 pKi 4000 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Binding affinity to human EP4 receptor expressed in HEK293 cells in presence of 10% human serum B 8.44 pKi 3.6 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
ChEMBL Binding affinity to human EP4 receptor expressed in HEK293 cells B 9.13 pKi 0.74 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
GtoPdb - - 9.15 pKi 0.7 nM Ki J Pharmacol Exp Ther (2008) 325: 425-34 [PMID:18287210]
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
ChEMBL Binding affinity to human FP receptor expressed in HEK293 cells B 5.7 pKi 2000 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Binding affinity to human IP receptor expressed in HEK293 cells B 5.15 pKi >7000 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Binding affinity to human TP receptor expressed in HEK293 cells B 6.2 pKi 630 nM Ki Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]