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ChEMBL ligand: CHEMBL1094250 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] | ||||||||
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay | B | 5.94 | pIC50 | 1140 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
Bcl-2-like 1/Apoptosis regulator Bcl-X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4625] [GtoPdb: 2845] [UniProtKB: Q07817] | ||||||||
ChEMBL | Binding affinity to Bcl-XL by isothermal titration calorimetric assay | B | 5.62 | pKd | 2400 | nM | Kd | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL | Binding affinity to Bcl-XL by isothermal titration calorimetric assay | B | 7 | pKd | 100 | nM | Kd | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay | B | 6.17 | pIC50 | 680 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay | B | 6.51 | pIC50 | 310 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
Bcl-2-related protein A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6044] [UniProtKB: Q16548] | ||||||||
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assay | B | 6.21 | pIC50 | 620 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assay | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
MCL1 apoptosis regulator, BCL2 family member/Induced myeloid leukemia cell differentiation protein Mcl-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4361] [GtoPdb: 2847] [UniProtKB: Q07820] | ||||||||
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL | Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assay | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2010) 53: 4166-4176 [PMID:20443627] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]