ChEMBL ligand: CHEMBL3137320 (BMN 673, BMN-673, LT-673, Talazoparib)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874] There should be some charts here, you may need to enable JavaScript!
poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by cell based assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2016) 59: 335-357 [PMID:26652717]
poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874]
ChEMBL	Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2016) 59: 335-357 [PMID:26652717]
ChEMBL	Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysis	B	8.92	pKi	1.2	nM	Ki	Eur J Med Chem (2019) 165: 198-215 [PMID:30684797]
ChEMBL	Inhibition of PARP1 (unknown origin) by ELISA	B	8.14	pIC50	7.2	nM	IC50	Eur J Med Chem (2017) 138: 514-531 [PMID:28692916]
ChEMBL	Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) and biotinylated NAD+ as substrate in presence of activated DNA incubated for 60 mins by chemiluminescence assay	B	9	pIC50	1	nM	IC50	Bioorg Med Chem (2020) 28: 115819-115819 [PMID:33120078]
ChEMBL	Inhibition of PARP1 (unknown origin)	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2015) 58: 3302-3314 [PMID:25761096]
ChEMBL	Inhibition of PARP1 (unknown origin)	B	9.24	pIC50	0.58	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4127-4132 [PMID:27353531]
ChEMBL	Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis	B	9.24	pIC50	0.57	nM	IC50	J Med Chem (2016) 59: 335-357 [PMID:26652717]
ChEMBL	Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysis	B	9.24	pIC50	0.57	nM	IC50	Eur J Med Chem (2019) 165: 198-215 [PMID:30684797]
ChEMBL	Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 0.5 hrs by fluorescence polarization assay based DNA trapping activity assay	B	8.49	pEC50	3.2	nM	EC50	J Med Chem (2020) 63: 15541-15563 [PMID:33264017]
poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5]
ChEMBL	Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysis	B	9.05	pKi	0.9	nM	Ki	Eur J Med Chem (2019) 165: 198-215 [PMID:30684797]
ChEMBL	Inhibition of human PARP2 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis	B	9.07	pKi	0.85	nM	Ki	J Med Chem (2016) 59: 335-357 [PMID:26652717]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]