elubirixin [Ligand Id: 8499] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2178579 (Elubrixin, Sb-656933, SB-656933, SB656933, SB-656933-AAF) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] | ||||||||
| ChEMBL | Binding affinity to CXCR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] | ||||||||
| ChEMBL | Antagonist activity at CXCR2 assessed as inhibition of neutrophil shape change | F | 6.51 | pIC50 | 310.5 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| ChEMBL | Antagonist activity at CXCR2 assessed as inhibition of neutrophil CD11b up-regulation | F | 6.58 | pIC50 | 260.7 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 | Pharmacol Rev (2014) 66: 1-79 [PMID:24218476] |
| ChEMBL | Binding affinity to CXCR2 | B | 8.29 | pIC50 | 5.1 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
