vialinin A [Ligand Id: 8669] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2012938 (Vialinin A) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SUMO specific peptidase 1/Sentrin-specific protease 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909484] [GtoPdb: 2414] [UniProtKB: Q9P0U3] | ||||||||
| ChEMBL | Binding affinity to full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3) | B | 5.97 | pKi | 1070 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4237-4240 [PMID:27491710] |
| ChEMBL | Binding affinity to recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli | B | 6.03 | pKi | 930 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4237-4240 [PMID:27491710] |
| ChEMBL | Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUMO1-AMC as substrate measured after 1 hr by fluorescence analysis | B | 5.72 | pIC50 | 1890 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 4237-4240 [PMID:27491710] |
| ChEMBL | Inhibition of full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by addition of SUMO1-AMC as substrate measured after 1 hr by fluorescence analysis | B | 5.79 | pIC50 | 1640 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 4237-4240 [PMID:27491710] |
| Ubiquitin carboxyl-terminal hydrolase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2406900] [UniProtKB: Q13107] | ||||||||
| ChEMBL | Inhibition of human USP4 using Ub-AMC as substrate after 60 mins by fluorometric analysis | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076] |
| ubiquitin specific peptidase 5/Ubiquitin carboxyl-terminal hydrolase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6158] [GtoPdb: 2431] [UniProtKB: P45974] | ||||||||
| ChEMBL | Competitive inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate | B | 4.9 | pKi | 12500 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076] |
| ChEMBL | Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate after 60 mins by fluorometric analysis | B | 5.4 | pKi | 4000 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076] |
| GtoPdb | - | - | 5.4 | pKi | 4000 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 4328-31 [PMID:23791076] |
| ChEMBL | Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate after 60 mins by fluorometric analysis | B | 5.23 | pIC50 | 5900 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076] |
| ubiquitin C-terminal hydrolase L1/Ubiquitin carboxyl-terminal hydrolase isozyme L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6159] [GtoPdb: 2426] [UniProtKB: P09936] | ||||||||
| ChEMBL | Inhibition of human UCH-L1 using Ub-AMC as substrate after 60 mins by fluorometric analysis | B | 4.65 | pIC50 | 22300 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
