ChEMBL ligand: CHEMBL515414
EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] There should be some charts here, you may need to enable JavaScript!
Transitional endoplasmic reticulum ATPase in Human [ChEMBL: CHEMBL1075145] [UniProtKB: P55072] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240] There should be some charts here, you may need to enable JavaScript!
Tyrosine-protein kinase SRC in Chicken [ChEMBL: CHEMBL3655] [UniProtKB: P00523] There should be some charts here, you may need to enable JavaScript!
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL	Inhibition of Eph-A2 in the presence of 50uM ATP	B	6.12	pIC50	760	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL	Inhibition of S6K1 in the presence of 20uM ATP	B	6.02	pIC50	950	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL	Inhibition of RSK2 C-terminal kinase domain expressed in Escherichia coli preincubated for 30 mins	B	4.82	pIC50	15000	nM	IC50	Science (2005) 308: 1318-1321 [PMID:15919995]
GtoPdb	-	-	7.82	pIC50	15	nM	IC50	Nat Chem Biol (2007) 3: 156-60 [PMID:17259979]
ChEMBL	Inhibition of His6-tagged RSK2 C-terminal domian expressed in Escherichia coli after 30 mins	B	7.82	pIC50	15	nM	IC50	Nat Chem Biol (2007) 3: 156-160 [PMID:17259979]
ChEMBL	Inhibition of RSK2 after 60 mins	B	7.82	pIC50	15	nM	IC50	J Med Chem (2011) 54: 3564-3574 [PMID:21488662]
ChEMBL	Inhibition of RSK2 transfected in HEK293 cells	B	7.82	pIC50	15	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]
ChEMBL	Inhibition of His6x-tagged RSK2 C-terminal domain (unknown origin) expressed in Escherichia coli	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2013) 21: 1724-1734 [PMID:23434140]
ChEMBL	Inhibition of RSK2 (unknown origin)	B	7.82	pIC50	15	nM	IC50	J Med Chem (2021) 64: 13572-13587 [PMID:34496560]
ChEMBL	Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by Western blotting analysis	B	6.82	pEC50	150	nM	EC50	Nat Chem Biol (2007) 3: 156-160 [PMID:17259979]
Transitional endoplasmic reticulum ATPase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075145] [UniProtKB: P55072]
ChEMBL	Inhibition of p97 in human HeLa cells assessed as reduction in proteasomal turnover of p97-dependent reporter substrate UbG76V-GFP incubated for 120 mins by luciferase reporter gene assay	B	4.33	pIC50	47000	nM	IC50	Eur J Med Chem (2021) 213: 113148-113148 [PMID:33476933]
ChEMBL	Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mins by biomol green reagent based assay	B	4.52	pIC50	>30000	nM	IC50	Eur J Med Chem (2021) 213: 113148-113148 [PMID:33476933]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	Inhibition of FYN Val285Cys mutant expressed in Escherichia coli	B	9	pIC50	1	nM	IC50	Science (2005) 308: 1318-1321 [PMID:15919995]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
ChEMBL	Inhibition of Lck in the presence of 50uM ATP	B	6.12	pIC50	750	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
Tyrosine-protein kinase SRC in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3655] [UniProtKB: P00523]
ChEMBL	Inhibition of Src in the presence of 50uM ATP	B	6.25	pIC50	560	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL	Inhibition of Yes in the presence of 20uM ATP	B	6.29	pIC50	510	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]