solabegron [Ligand Id: 9512] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL208427 (Gw427353, Solabegron) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cells | B | 6.4 | pKi | 398.11 | nM | Ki | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| GtoPdb | - | - | 5.4 | pEC50 | - | - | - | J Med Chem (2006) 49: 2758-71 [PMID:16640337] |
| ChEMBL | Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production | F | 5.4 | pEC50 | 3981.07 | nM | EC50 | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cells | B | 5.8 | pKi | 1584.89 | nM | Ki | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| ChEMBL | Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production | F | 5.9 | pEC50 | 1258.93 | nM | EC50 | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| GtoPdb | - | - | 5.9 | pEC50 | - | - | - | J Med Chem (2006) 49: 2758-71 [PMID:16640337] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| ChEMBL | Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP production | F | 8.4 | pEC50 | 3.98 | nM | EC50 | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| GtoPdb | - | - | 8.7 | pEC50 | - | - | - |
J Med Chem (2006) 49: 2758-71 [PMID:16640337]; Pharmacol Ther (2016) 159: 66-82 [PMID:26808167]; Naunyn Schmiedebergs Arch Pharmacol (2013) 386: 177-83 [PMID:23263450] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
