compound 2g [PMID: 27390066] [Ligand Id: 9682] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3355101 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144] | ||||||||
| ChEMBL | Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | B | 8.62 | pKi | 2.4 | nM | Ki | J Med Chem (2014) 57: 8140-8151 [PMID:25192493] |
| Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145] | ||||||||
| ChEMBL | Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | B | 7.16 | pKi | 69 | nM | Ki | J Med Chem (2014) 57: 8140-8151 [PMID:25192493] |
| Cytosol aminopeptidase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5624] [UniProtKB: P28839] | ||||||||
| ChEMBL | Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation | B | 6.67 | pKi | 215 | nM | Ki | J Med Chem (2014) 57: 8140-8151 [PMID:25192493] |
| Endoplasmic reticulum aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08] | ||||||||
| ChEMBL | Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method | B | 6.28 | pKi | 530 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-4126 [PMID:27390066] |
| GtoPdb | - | - | 6.28 | pKi | 530 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-6 [PMID:27390066] |
| Endoplasmic reticulum aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179] | ||||||||
| ChEMBL | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | B | 6.82 | pKi | 152 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-4126 [PMID:27390066] |
| GtoPdb | - | - | 6.82 | pKi | 150 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4122-6 [PMID:27390066] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
