Synonyms: Example 2 [WO2021111124A1] | STC15
Compound class:
Synthetic organic
Comment: STC-15 is an oral small molecule inhibitor of the the RNA methyltransferase METTL3. METTL3 'writes' N6-methyladenosine (m6A) modifications on mRNA and long non-coding RNA (lncRNA) targets, and these modifications regulate the stability, splicing, transport and translation of the m6A RNAs. METTL3‑mediated methylation has been implicated in the potentiation of tumour growth, cell invasion and metastasis. Inhibition of METTL3 function is proposed to induce anti-cancer immunity and reduce cancer growth [2-3].
The structure of STC-15 was disclosed at the American Chemical Society (ACS) meeting in August 2023. It is one of the compounds claimed in Storm Therapeutics' patent WO2021111124A1 [1]. Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Selectivity at enzymes | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|