STC-15   Click here for help

GtoPdb Ligand ID: 12894

Synonyms: Example 2 [WO2021111124A1] | STC15
Compound class: Synthetic organic
Comment: STC-15 is an oral small molecule inhibitor of the the RNA methyltransferase METTL3. METTL3 'writes' N6-methyladenosine (m6A) modifications on mRNA and long non-coding RNA (lncRNA) targets, and these modifications regulate the stability, splicing, transport and translation of the m6A RNAs. METTL3‑mediated methylation has been implicated in the potentiation of tumour growth, cell invasion and metastasis. Inhibition of METTL3 function is proposed to induce anti-cancer immunity and reduce cancer growth [2-3].
The structure of STC-15 was disclosed at the American Chemical Society (ACS) meeting in August 2023. It is one of the compounds claimed in Storm Therapeutics' patent WO2021111124A1 [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 85.83
Molecular weight 415.49
XLogP 1
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES C1=CC2=NC(=CC(=O)N2C=C1)C(=O)NCC3=CC4=C(C=C3)C=C(CNCC5CCC5)N4
Isomeric SMILES O=C(NCC1=CC2=C(C=C(CNCC3CCC3)N2)C=C1)C4=CC(=O)N5C=CC=CC5=N4
InChI InChI=1S/C24H25N5O2/c30-23-12-21(28-22-6-1-2-9-29(22)23)24(31)26-14-17-7-8-18-11-19(27-20(18)10-17)15-25-13-16-4-3-5-16/h1-2,6-12,16,25,27H,3-5,13-15H2,(H,26,31)
InChI Key MFQFZLWCFZZHAI-UHFFFAOYSA-N
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Hs Inhibitor Inhibition 8.2 pIC50 - 1
pIC50 8.2 (IC50 6.1x10-9 M) [1]