Synonyms: MMV687696 | Q203
Compound class:
Synthetic organic
Comment: Telacebec is a first-in-class imidazopyridine amide that inhibits the mycobacterial cytochrome bc1 complex [3]. It is being clinically evaluated as a treatment for tuberculosis (TB).
Telacebec was one of the compounds with activity against Mycobacterium tuberculosis included in the Medicines for Malaria Venture (MMV) Pathogen Box (see MMVOpen for futher details). |
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References |
1. de Jager VR, Dawson R, van Niekerk C, Hutchings J, Kim J, Vanker N, van der Merwe L, Choi J, Nam K, Diacon AH. (2020)
Telacebec (Q203), a New Antituberculosis Agent. N Engl J Med, 382 (13): 1280-1281. [PMID:32212527] |
2. Nguyen TQ, Hanh BTB, Jeon S, Heo BE, Park Y, Choudhary A, Moon C, Jang J. (2022)
Synergistic Effect of Q203 Combined with PBTZ169 against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 66 (12): e0044822. [PMID:36321819] |
3. Pethe K, Bifani P, Jang J, Kang S, Park S, Ahn S, Jiricek J, Jung J, Jeon HK, Cechetto J et al.. (2013)
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med, 19 (9): 1157-60. [PMID:23913123] |