sotatercept   Click here for help

GtoPdb Ligand ID: 12962

Synonyms: ACE-011 | ACE011 | ActRIIA-IgG1 | MK-7962 | MK7962
Compound class: Antibody
Comment: Sotatercept (MK-7962) is a soluble activin receptor 2A (ACVR2A; ActR2) ligand trap type inhibitor. Structurally it is a fusion protein of the extracellular domain of the ActR2 and a human IgG Fc domain. In pulmonary blood vessels sotatercept sequesters ActR2 endogenous ligands (e.g. activins A and B, and growth differentiation factors 8 and 11, BMP6 and BMP7), and prevents their interaction with ActR2s to restore normal cell proliferation [2,5].
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
9188 sotatercept
Synonyms Click here for help
ACE-011 | ACE011 | ActRIIA-IgG1 | MK-7962 | MK7962
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 331
Other databases
GtoPdb PubChem SID 485206083
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