glibenclamide

Ligand Id: 2414
Ligand name glibenclamide

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 121.98
Molecular weight 493.14
XLogP 4.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK


Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (as glyburide, 1984))
DrugBank groups approved
IUPAC Name
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
International Nonproprietary Names
INN number INN
2386 glibenclamide
Synonyms
glyburide
Database Links
BindingDB Ligand 50012957
CAS Registry No. 10238-21-8
ChEBI CHEBI:5441
ChEMBL Ligand CHEMBL472
DrugBank Ligand DB01016
PharmGKB Drug PA449782
PubChem CID 3488
Search Google for chemical match using the InChIKey ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZNNLBTZKUZBEKO
Search PubMed clinical trials glibenclamide
Search PubMed titles glibenclamide
Search PubMed titles/abstracts glibenclamide
Wikipedia Glibenclamide
ZINC ZINC00537805
Comments
A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 (KCNJ11)