glibenclamide

Ligand id: 2414

Name: glibenclamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 121.98
Molecular weight 493.14
XLogP 4.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (as glyburide, 1984))
IUPAC Name
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
International Nonproprietary Names
INN number INN
2386 glibenclamide
Synonyms
Diabeta® | glyburide | Glynase®
Comments
A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 (KCNJ11). Glibenclamide induced blockade of SUR1-TRPM4 channels reduces inflammatory markers and improves clinical symptoms in mouse experimental autoimmune encephalomyelitis (EAE), and may be of relevance in multiple sclerosis as SUR1-TRPM4-expressing lesions from MS provide a potentially disease modiifying target [1].
Database Links
BindingDB Ligand 50012957
CAS Registry No. 10238-21-8
ChEBI CHEBI:5441
ChEMBL Ligand CHEMBL472
DrugBank Ligand DB01016
GtoPdb PubChem SID 135650306
PubChem CID 3488
RCSB PDB Ligand GBM
Search Google for chemical match using the InChIKey ZNNLBTZKUZBEKO-UHFFFAOYSA-N
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Search UniChem for chemical match using the InChIKey ZNNLBTZKUZBEKO-UHFFFAOYSA-N
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Wikipedia Glibenclamide

Product suppliers

Tocris
Glibenclamide
Cat. No. 0911