glibenclamide

Ligand id: 2414

Name: glibenclamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 121.98
Molecular weight 493.14
XLogP 4.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
OATP2B1
Selectivity at human ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
CFTR Channel blocker - 4.7 pKi - 6
pKi 4.7 (Ki 2.18x10-5 M) [6]
Kir6.1 Inhibitor - - - -
Kir6.2 Inhibitor - - - -
Selectivity at human transporters
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Target Type Action Affinity Units Concentration range (M) Reference
OATP2B1 Inhibitor Inhibition - - -
Selectivity at mouse ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
Kir6.2 Channel blocker Antagonist 5.7 pIC50 1x10-6 1-2
pIC50 5.7 Conc range: 1x10-6 M [1-2]
Voltage: Physiological / -60.0 mV
Selectivity at rat ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
Kir6.2 Channel blocker Antagonist - - 1x10-6 3
Conc range: 1x10-6 M [3]
Voltage: -60.0 mV