glibenclamide

Ligand id: 2414

Name: glibenclamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 121.98
Molecular weight 493.14
XLogP 4.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
OATP2B1
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kir6.2 Rn Channel blocker Antagonist - - 1x10-6 3
Conc range: 1x10-6 M [3]
Voltage: -60.0 mV
CFTR Hs Channel blocker - 4.7 pKi - 6
pKi 4.7 (Ki 2.18x10-5 M) [6]
Kir6.2 Mm Channel blocker Antagonist 5.7 pIC50 1x10-6 1-2
pIC50 5.7 Conc range: 1x10-6 M [1-2]
Voltage: Physiological / -60.0 mV
Kir6.1 Hs Inhibitor - - - -
Kir6.2 Hs Inhibitor - - - -
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
OATP2B1 Hs Inhibitor Inhibition - - -