SLC15 family of peptide transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC15 family of peptide transporters may be divided on the basis of structural and functional differences into two subfamilies: SLC15A1 (PepT1) and SLC15A2 (PepT2) transport di- and tripeptides, but not amino acids, whereas SLC15A3 (PHT2) and SLC15A4 (PHT1) transport L-histidine and some di- and tripeptides [5]. The transporters are 12 TM proteins with intracellular termini and an extended extracellular loop at TM 9/10. The crystal structure of PepTSo (a prokaryote homologue of PepT1 and PepT2 from Shewanella oneidensis) confirms many of the predicted structural features of mammalian PepT1 and PepT2 [15].

PHT1 has been suggested to be intracellular [16], while PHT2 protein is located on lysosomes in transfected cells [4,11,18]. PHT1 is hypothesised to mediate efflux of bacterial-derived peptides into the cytosol perhaps in the colon where SLC15A4 mRNA expression is increased in inflammatory bowel disease [13]. Transport via PHT1 may be important in immune responses as both Toll-like receptor- and NOD1-mediated responses are reduced in PHT1 knockout mice or mouse strains expressing mutations in PHT1 [3,19].

Transporters

PepT1 (Peptide transporter 1 / SLC15A1) Show summary »

PepT2 (Peptide transporter 2 / SLC15A2) Show summary »

PHT2 (Peptide transporter 3 / SLC15A3) Show summary »

PHT1 (Peptide transporter 4 / SLC15A4) Show summary »

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How to cite this family page

Database page citation:

SLC15 family of peptide transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=187.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.