Peptide transporter 3

Target id: 986

Nomenclature: Peptide transporter 3

Abbreviated Name: PHT2

Systematic Nomenclature: SLC15A3

Family: SLC15 family of peptide transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Peptide transporter 3 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC15A3 solute carrier family 15 member 3
Mouse - - Slc15a3 solute carrier family 15, member 3
Rat - - Slc15a3 solute carrier family 15 member 3
Previous and Unofficial Names
solute carrier family 15 | peptide/histidine transporter PHT2 | PTR3 | solute carrier family 15 member 3 | solute carrier family 15 (oligopeptide transporter), member 3
Database Links
Specialist databases
Bioparadigms SLC Tables SLC15A3 (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
muramyl dipeptide Hs - - 1
histidyl-leucine Hs - - 2
MDP-rhodamine Hs - - 1
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[14C]histidine Hs - - - 2
[3H]histidine Hs - - - 2
Immunopharmacology Comments
SLC15A3 and SLC15A4, are preferentially expressed by dendritic cells, especially after TLR stimulation [1].
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
References:  1


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1. Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I. (2014) Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature, 509 (7499): 240-4. [PMID:24695226]

2. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. (2001) Cloning of a lymphatic peptide/histidine transporter. Biochem. J., 356 (Pt 1): 53-60. [PMID:11336635]


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How to cite this page

David T. Thwaites, Tiziano Verri.
SLC15 family of peptide transporters: Peptide transporter 3. Last modified on 07/11/2017. Accessed on 25/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY,