rifamycin SV

Ligand id: 4570

Name: rifamycin SV

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 3
Topological polar surface area 201.31
Molecular weight 697.31
XLogP 3.97
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Approved drug? Yes (FDA (2018))
IUPAC Name
(7S,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
International Nonproprietary Names
INN number INN
2293 rifamycin
Synonyms
Aemcolo®
Comments
One of the Ansamycin group of antibiotics. Rifamycin is a natural antibiotic that is produced by Streptomyces mediterranei that exhibits antibiotic and antitubercular properties. Rifamycins are particularly effective against mycobacteria, and are most commonly used to treat tuberculosis, leprosy, and mycobacterium avium complex (MAC) infections.
Database Links
CAS Registry No. 6998-60-3 (source: Scifinder)
ChEBI CHEBI:29673
ChEMBL Ligand CHEMBL437765
GtoPdb PubChem SID 178101291
PubChem CID 6324616
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