olanzapine

Ligand id: 47

Name: olanzapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 59.11
Molecular weight 312.14
XLogP 3.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
IUPAC Name
2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
International Nonproprietary Names
INN number INN
6956 olanzapine
Synonyms
LY-170053 | Zyprexa®
Database Links
BindingDB Ligand 50053711
CAS Registry No. 132539-06-1
DrugBank Ligand DB00334
PubChem CID 4585
Search Google for chemical match using the InChIKey WXPNDRBBWZMPQG-UHFFFAOYSA-N
Search Google for chemicals with the same backbone WXPNDRBBWZMPQG
Search PubMed clinical trials olanzapine
Search PubMed titles olanzapine
Search PubMed titles/abstracts olanzapine
Search UniChem for chemical match using the InChIKey WXPNDRBBWZMPQG-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone WXPNDRBBWZMPQG
Wikipedia Olanzapine
Comments
Olanzapine displays affinity for numerous receptors from the serotonin, histamine, alpha adrenergic, dopamine and muscarinic acetylcholine receptor families. Its antipsychotic properties are believed to arise from its antagonism of the dopamine D2 and 5-HT2A receptors.
Marketed formulations may contain olanzapine pamoate (PubChem CID 12085238). Olanzapine is represented on some databases with some of the double bonds in a different position. See CHEBI:7735 and CHEMBL715.