olanzapine

Ligand id: 47

Name: olanzapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 59.11
Molecular weight 312.14
XLogP 3.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antipsychotic used in the treatment of schizophrenia and other psychotic illnesses, including bipolar disorder.
Mechanism Of Action and Pharmacodynamic Effects
Antagonism of dopamine D2 receptors in the mesolimbic pathway relieves positive symptoms of schizophrenia (such as delusions, disordered thoughts and speech, and hallucinations), while antagonism of 5-HT2A receptors in the frontal cortex may contribute to the drug's ability to ease the negative symptoms of schizophrenia (such as emotional and thought defecits).
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