floxuridine

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Ligands
floxuridine

Ligand id: 4801

Name: floxuridine

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	7
Hydrogen bond donors	3
Rotatable bonds	2
Topological polar surface area	99.1
Molecular weight	246.07
XLogP	-1.23
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (1970))
Is prodrug?	Yes
Active form	5-fluorouracil

IUPAC Name
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

IUPAC Name

5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

International Nonproprietary Names
INN number	INN
2010	floxuridine

Synonyms
5-fluoro-2'-deoxyuridine
floxidine
FUDR®

Synonyms

5-fluoro-2'-deoxyuridine

floxidine

FUDR®

Database Links
CAS Registry No.	50-91-9 (source: Scifinder)
ChEMBL Ligand	CHEMBL917
DrugBank Ligand	DB00322
PubChem CID	5790
Search Google for chemical match using the InChIKey	ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Search Google for chemicals with the same backbone	ODKNJVUHOIMIIZ
Search PubMed clinical trials	floxuridine
Search PubMed titles	floxuridine
Search PubMed titles/abstracts	floxuridine
Wikipedia	Floxuridine

Comments
Floxuridine is metabolized to 5-fluorouracil when given by rapid injection, but is converted to floxuridine monophosphate when given as continuous infusion. 5-fluorouracil is considered the active drug.

Comments

Floxuridine is metabolized to 5-fluorouracil when given by rapid injection, but is converted to floxuridine monophosphate when given as continuous infusion. 5-fluorouracil is considered the active drug.