floxuridine

Ligand id: 4801

Name: floxuridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 99.1
Molecular weight 246.07
XLogP -1.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1970))
Is prodrug? Yes
Active form 5-fluorouracil
IUPAC Name
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
International Nonproprietary Names
INN number INN
2010 floxuridine
Synonyms
5-fluoro-2'-deoxyuridine | floxidine | FUDR®
Database Links
CAS Registry No. 50-91-9 (source: Scifinder)
ChEMBL Ligand CHEMBL917
DrugBank Ligand DB00322
GtoPdb PubChem SID 178101503
PubChem CID 5790
Search Google for chemical match using the InChIKey ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Search Google for chemicals with the same backbone ODKNJVUHOIMIIZ
Search PubMed clinical trials floxuridine
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Search UniChem for chemical match using the InChIKey ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Search UniChem for chemicals with the same backbone ODKNJVUHOIMIIZ
Wikipedia Floxuridine
Comments
Floxuridine is metabolized to 5-fluorouracil when given by rapid injection, but is converted to floxuridine monophosphate when given as continuous infusion. 5-fluorouracil is considered the active drug.