floxuridine

Ligand id: 4801

Name: floxuridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 99.1
Molecular weight 246.07
XLogP -1.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Floxuridine is used to treat cancers of the digestive system, especially where hepatic metastases have developed.
Mechanism Of Action and Pharmacodynamic Effects
5-fluorouracil intereferes with DNA and RNA synthesis. The primary effect is on DNA synthesis, where the fluoroacil mimics normal pyrimidines, and prevents their incorporation into DNA during the S phase of the cell cycle, thus initiating cell death.
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